Treatment failure in Haemophilus influenzae due to a beta-lactamase low-level ampicillin-resistant organism

Summary Haemophilus influenzae is a rare causative organism of vertebral osteomyelitis in an adult. Cases reported in the literature were mainly caused by ampicillin-susceptible type b strains. Here we describe the first case of vertebral osteomyelitis due to a non-typeable, beta-lactamase low-level...

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Bibliographic Details
Published in:The Journal of infection 2008-12, Vol.57 (6), p.485-488
Main Authors: van der Ploeg, Vishnu, Gelinck, Luc B.S, Jonkers, Iris J.A.M, Mourer, Jacqueline S, van Dam, Alje P
Format: Article
Language:English
Subjects:
Aged
Amoxicillin - therapeutic use
Ampicillin Resistance
Anti-Bacterial Agents - therapeutic use
beta-Lactamases - biosynthesis
Biological and medical sciences
BLNAR
General aspects
Haemophilus Infections - drug therapy
Haemophilus Infections - microbiology
Haemophilus influenzae
Haemophilus influenzae - drug effects
Haemophilus influenzae - enzymology
Haemophilus influenzae - isolation & purification
Humans
Infectious Disease
Infectious diseases
Male
Medical sciences
Non-typeable
Osteomyelitis - drug therapy
Osteomyelitis - microbiology
Spondylitis
Treatment Failure
Vertebral osteomyelitis
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Summary:Summary Haemophilus influenzae is a rare causative organism of vertebral osteomyelitis in an adult. Cases reported in the literature were mainly caused by ampicillin-susceptible type b strains. Here we describe the first case of vertebral osteomyelitis due to a non-typeable, beta-lactamase low-level ampicillin-resistant H. influenzae strain with failure of prolonged intravenous amoxicillin treatment.
ISSN:0163-4453
1532-2742
DOI:10.1016/j.jinf.2008.06.024