Update on vitamin D and evaluation of vitamin D status

Knowledge about vitamin D has greatly improved during the last few years. Vitamin D cannot any more be considered as exclusively necessary to prevent ricket/osteomalacia. Its role in the prevention of some osteoporotic fractures in the elderly (in association with calcium nutrition) is now well demo...

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Bibliographic Details
Published in:Annales d'endocrinologie 2008-12, Vol.69 (6), p.501-510
Main Authors: Souberbielle, J-C, Prié, D, Courbebaisse, M, Friedlander, G, Houillier, P, Maruani, G, Cavalier, E, Cormier, C
Format: Article
Language:fre
Subjects:
Animals
Humans
Immune System - physiology
Muscle, Skeletal - physiology
Neoplasms - physiopathology
Nutritional Status - physiology
Vitamin D - blood
Vitamin D - physiology
Vitamin D Deficiency - diagnosis
Vitamins - physiology
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Summary:Knowledge about vitamin D has greatly improved during the last few years. Vitamin D cannot any more be considered as exclusively necessary to prevent ricket/osteomalacia. Its role in the prevention of some osteoporotic fractures in the elderly (in association with calcium nutrition) is now well demonstrated and many epidemiologic and laboratory data argue for a role in the prevention of several diseases or anomalies (cancer, auto-immune diseases, cardiovascular events, sarcopenia...). A few intervention studies confirming some of these effects also exist. Vitamin D status can easily be assessed by measuring serum 25 hydroxy vitamin D (25OHD) level. However, many experts have claimed that the population-based reference values for 25OHD are too low and that the cut-off value below which vitamin D insufficiency can be present is somewhere between 20 and 40 ng/mL with a clear tendency to target values above 30 ng/mL (75 nmol/L). The main consequences are that vitamin D insufficiency is highly frequent whereas the currently recommended supplementation doses are not sufficient.
ISSN:0003-4266
DOI:10.1016/j.ando.2008.07.010