Impact of Right Ventricular Volume Overload on Three-Dimensional Global Left Ventricular Mechanical Dyssynchrony After Surgical Repair of Tetralogy of Fallot

This study aimed to test the hypothesis that right ventricular (RV) volume overload may result in left ventricular (LV) systolic dysfunction through induction of LV systolic dyssynchrony after tetralogy of Fallot (TOF) repair. Sixty patients with TOF repair were studied at 14.3 ± 7.2 years after TOF...

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Published in:The American journal of cardiology 2008-12, Vol.102 (12), p.1731-1736
Main Authors: Liang, Xue-cun, MD, Cheung, Eddie Wai-yin, MBBS, MMedSc, Wong, Sophia Jessica, BSc, Cheung, Yiu-fai, MD
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
Cardiac Volume
Cardiology
Cardiology. Vascular system
Cardiovascular
Case-Control Studies
Echocardiography
Female
Heart
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Heart surgery
Heart Ventricles - diagnostic imaging
Heart Ventricles - physiopathology
Humans
Male
Medical sciences
Multivariate analysis
Postoperative Complications - diagnostic imaging
Postoperative Complications - etiology
Studies
Surgical techniques
Tetralogy of Fallot - complications
Tetralogy of Fallot - physiopathology
Tetralogy of Fallot - surgery
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Dysfunction, Left - etiology
Ventricular Dysfunction, Right - complications
Young Adult
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Summary:This study aimed to test the hypothesis that right ventricular (RV) volume overload may result in left ventricular (LV) systolic dysfunction through induction of LV systolic dyssynchrony after tetralogy of Fallot (TOF) repair. Sixty patients with TOF repair were studied at 14.3 ± 7.2 years after TOF repair. Real-time 3-dimensional echocardiographic data sets were acquired for measurement of LV and RV volumes and derivation of ejection fractions and pulmonary regurgitant volume. The LV systolic dyssynchrony index (SDI) was derived from the dispersion of time to minimum regional volume using a 16-segment model. The results were compared with those of 29 healthy controls. LV SDI was significantly higher in patients than controls (7.4% ± 2.0% vs 3.0% ± 0.9%, p 4.7%) in patients was 93% (95% confidence interval 87% to 100%). The time to minimum regional volume was significantly longer in all of the 6 basal segments and the midposterior segment (all p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2008.07.062