Elevation of CD5 + B lymphocytes in schizophrenia

Background: A variety of immunologic alterations have been observed in patients with schizophrenia. These findings have lent support to theories that autoimmune mechanisms may be important in some patients with the illness. The CD5 + B lymphocyte, a B-cell subset associated with autoimmune disease,...

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Bibliographic Details
Published in:Biological psychiatry (1969) 1999-07, Vol.46 (1), p.110-118
Main Authors: Printz, David J., Strauss, David H., Goetz, Raymond, Sadiq, Saud, Malaspina, Dolores, Krolewski, John, Gorman, Jack M.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
antipsychotic
autoimmunity
Biological and medical sciences
CD5 + B lymphocyte
CD5 Antigens - blood
CD5 Antigens - immunology
CD8 Antigens - blood
CD8 Antigens - immunology
Female
Flow Cytometry - methods
Humans
Male
Medical sciences
pathophysiology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - blood
Schizophrenia - immunology
T-Lymphocyte Subsets - immunology
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Summary:Background: A variety of immunologic alterations have been observed in patients with schizophrenia. These findings have lent support to theories that autoimmune mechanisms may be important in some patients with the illness. The CD5 + B lymphocyte, a B-cell subset associated with autoimmune disease, has been the subject of two previously published studies yielding disparate results. Methods: In this study, we used immunofluorescent flow cytometry to measure CD5 + B cells, total B and T cells, and CD4 and CD8 subsets in patients with schizophrenia and in normal control subjects. Results: A significantly higher percentage of patients with schizophrenia, relative to normal control subjects, exhibited an elevated level of CD5 + B cells (27.6% vs 6.7%). Antipsychotic withdrawal had no effect on CD5 + B-cell levels, suggesting that medication effects were not the cause of this difference. No other studied lymphocyte subsets differed between the two groups. Conclusions: A subset of patients with schizophrenia have elevated levels of CD5 + B cells. This finding replicates an earlier study by another group and provides further evidence suggestive of autoimmune manifestations in schizophrenia.
ISSN:0006-3223
1873-2402
DOI:10.1016/S0006-3223(98)00307-2