Paraneoplastic neurological syndromes in patients with carcinoid

Background:  Paraneoplastic neurological syndromes (PNS) are mainly associated with small‐cell lung cancer, gynaecological tumours and lymphomas. Few studies report the association of neurological syndromes with a carcinoid, the majority being a serotonin‐related myopathy. We report four patients wi...

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Bibliographic Details
Published in:European journal of neurology 2008-12, Vol.15 (12), p.1390-1394
Main Authors: Tschernatsch, M., Dierkes, C., Gerriets, T., Hosch, J., Stolz, E., Kaps, M., Krasenbrink, I., Claus, D., Blaes, F.
Format: Article
Language:English
Subjects:
Aged
anti-Hu
anti-Yo
antineuronal
autoantibodies
Autoantibodies - immunology
Biomarkers - analysis
Biomarkers - metabolism
carcinoid
Carcinoid Tumor - complications
Carcinoid Tumor - pathology
Carcinoid Tumor - physiopathology
ELAV Proteins - immunology
Encephalitis - etiology
Encephalitis - pathology
Encephalitis - physiopathology
Female
Humans
Limbic Encephalitis - pathology
Limbic Encephalitis - physiopathology
Male
Middle Aged
Nerve Tissue Proteins - immunology
paraneoplastic neurological syndrome
Paraneoplastic Polyneuropathy - pathology
Paraneoplastic Polyneuropathy - physiopathology
Paraneoplastic Syndromes - etiology
Paraneoplastic Syndromes - pathology
Paraneoplastic Syndromes - physiopathology
Spinal Cord Diseases - etiology
Spinal Cord Diseases - pathology
Spinal Cord Diseases - physiopathology
Young Adult
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Summary:Background:  Paraneoplastic neurological syndromes (PNS) are mainly associated with small‐cell lung cancer, gynaecological tumours and lymphomas. Few studies report the association of neurological syndromes with a carcinoid, the majority being a serotonin‐related myopathy. We report four patients with a PNS associated with carcinoid. Patients and results:  The clinical syndromes were sensory neuropathy, limbic encephalitis, myelopathy and brain stem encephalitis. Two patients had antineuronal autoantibodies (one anti‐Hu, one anti‐Yo), one patient had antinuclear antibodies, and one patient had no autoantibodies. For two of the carcinoids, expression of HuD in the tumour could be demonstrated. Conclusion:  This study demonstrates that carcinoids can also be associated with classical antineuronal antibody‐associated PNS.
ISSN:1351-5101
1468-1331
1471-0552
DOI:10.1111/j.1468-1331.2008.02328.x