Structure and function of the LysR-type transcriptional regulator (LTTR) family proteins

1 Department of Oral and Dental Science, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK 2 Biomedical Sciences, DSTL Porton Down, Salisbury SP4 0JQ, UK Correspondence Sarah E. Maddocks sarah.maddocks{at}bristol.ac.uk The LysR family of transcriptional regulators represents the most...

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Published in:Microbiology (Society for General Microbiology) 2008-12, Vol.154 (12), p.3609-3623
Main Authors: Maddocks, Sarah E, Oyston, Petra C. F
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Bacteria - genetics
Bacteria - metabolism
Bacterial Proteins - chemistry
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Bacteriology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Bacterial
Genetics
Metabolism. Enzymes
Microbiology
Models, Molecular
Molecular Sequence Data
Structure-Activity Relationship
Transcription Factors - chemistry
Transcription Factors - genetics
Transcription Factors - metabolism
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Summary:1 Department of Oral and Dental Science, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK 2 Biomedical Sciences, DSTL Porton Down, Salisbury SP4 0JQ, UK Correspondence Sarah E. Maddocks sarah.maddocks{at}bristol.ac.uk The LysR family of transcriptional regulators represents the most abundant type of transcriptional regulator in the prokaryotic kingdom. Members of this family have a conserved structure with an N-terminal DNA-binding helix–turn–helix motif and a C-terminal co-inducer-binding domain. Despite considerable conservation both structurally and functionally, LysR-type transcriptional regulators (LTTRs) regulate a diverse set of genes, including those involved in virulence, metabolism, quorum sensing and motility. Numerous structural and transcriptional studies of members of the LTTR family are helping to unravel a compelling paradigm that has evolved from the original observations and conclusions that were made about this family of transcriptional regulators. Abbreviations: ABS, activation binding site; DBD, DNA-binding domain; HTH, helix–turn–helix; wHTH, winged-HTH; LTTR, LysR-type transcriptional regulator; RBS, regulatory binding site
ISSN:1350-0872
1465-2080
DOI:10.1099/mic.0.2008/022772-0