Study of hepatitis C virus leukotropism by characterization of viral quasispecies in the liver transplantation setting

Besides hepatocytes, representing the main replication site of hepatitis C virus, peripheral blood mononuclear cells also represent a crucial target for viral infection. Hepatitis C virus compartmentalization (i.e., non-random distribution) of viral variants between plasma and peripheral blood monon...

Full description

Saved in:
Bibliographic Details
Published in:Pathologie biologie (Paris) 2008-11, Vol.56 (7-8), p.487-491
Main Authors: Schramm, F, Moenne-Loccoz, R, Fafi-Kremer, S, Soulier, E, Royer, C, Weitten, T, Brignon, N, Ellero, B, Woehl-Jaegle, M-L, Meyer, C, Wolf, P, Doffoel, M, Baumert, T-F, Gut, J-P, Stoll-Keller, F, Schvoerer, E
Format: Article
Language:fre
Subjects:
Blood Cells - virology
Cohort Studies
Cryoglobulinemia - virology
Hepacivirus - genetics
Hepacivirus - growth & development
Hepacivirus - isolation & purification
Hepacivirus - physiology
Hepatitis C, Chronic - complications
Hepatitis C, Chronic - surgery
Hepatitis C, Chronic - virology
Hepatocytes - virology
Humans
Leukocytes, Mononuclear - virology
Liver - virology
Liver Cirrhosis - etiology
Liver Cirrhosis - surgery
Liver Cirrhosis - virology
Liver Transplantation
Lymphoma, Non-Hodgkin - virology
Organ Specificity
Polymorphism, Single-Stranded Conformational
Viral Envelope Proteins - genetics
Virus Replication
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Besides hepatocytes, representing the main replication site of hepatitis C virus, peripheral blood mononuclear cells also represent a crucial target for viral infection. Hepatitis C virus compartmentalization (i.e., non-random distribution) of viral variants between plasma and peripheral blood mononuclear cells, more frequently observed in liver transplant patients compared to non-transplanted patients, makes liver transplantation an interesting model for the analysis of hepatitis C leukotropism. This article aims to present, firstly, in clinical and biological features arguing favour of hepatitis C virus infection leukotropism and, secondly, to review current knowledge about compartmentalization between plasma and peripheral blood mononuclear cells, especially in the liver transplantation setting.
ISSN:0369-8114
1768-3114
DOI:10.1016/j.patbio.2008.07.007