Splenic and Hepatic Hemozoin in Mice after Malaria Parasite Clearance

Hemozoin (malaria pigment) is found in many tissues during malaria infections. In mice that have self-cured from Plasmodium yoelii and Plasmodium chabaudi infections, liver hemozoin concentration and total content decreased for 6-9 mo after parasite clearance. However, both spleen hemozoin concentra...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of parasitology 1999-06, Vol.85 (3), p.570-573
Main Authors: LEVESQUE, M. A, SULLIVAN, A. D, MESHNICK, S. R
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Experimental protozoal diseases and models
Hemeproteins - analysis
Infections
Infectious diseases
Liver
Liver - chemistry
Liver - pathology
Macrophages
Malaria
Malaria - metabolism
Male
Medical sciences
Mice
Mice, Inbred ICR
Organ Size
Parasitemia
Parasites
Parasitic diseases
Parasitology
Pigments
Pigments, Biological - analysis
Plasmodium chabaudi
Plasmodium chabaudi - physiology
Plasmodium yoelii
Plasmodium yoelii - physiology
Protozoal diseases
Research Notes
Spleen
Spleen - chemistry
Spleen - pathology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hemozoin (malaria pigment) is found in many tissues during malaria infections. In mice that have self-cured from Plasmodium yoelii and Plasmodium chabaudi infections, liver hemozoin concentration and total content decreased for 6-9 mo after parasite clearance. However, both spleen hemozoin concentration and total hemozoin content increased dramatically during this time period. Thus, hemozoin or hemozoin-laden macrophages continue to accumulate in murine spleens for at least several months after malaria parasitemia becomes undetectable.
ISSN:0022-3395
1937-2345
DOI:10.2307/3285800