Avian NK activities, cells and receptors

Abstract Natural killer (NK) activity has been examined in birds for over 30 years, but evidence that avian NK activity plays crucial roles in disease is only suggestive. In chickens, NK activity is mediated by TCR0 cells in the intestinal epithelium, but elsewhere subsets of αβ and γδ T cells (NKT...

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Bibliographic Details
Published in:Seminars in immunology 2008-12, Vol.20 (6), p.353-360
Main Authors: Rogers, Sally L, Viertlboeck, Birgit C, Göbel, Thomas W, Kaufman, Jim
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
B-NK
Bird
Birds - genetics
Birds - immunology
Chicken
Chickens - genetics
Chickens - immunology
CHIR
Communicable Diseases - immunology
Intestines - cytology
Intestines - immunology
Killer Cells, Natural - cytology
Killer Cells, Natural - immunology
Killer Cells, Natural - metabolism
Lymphocytes - cytology
Lymphocytes - immunology
Natural killer
Natural Killer T-Cells - cytology
Natural Killer T-Cells - immunology
Receptors, Immunologic - physiology
Receptors, Natural Killer Cell - immunology
Receptors, Natural Killer Cell - metabolism
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Summary:Abstract Natural killer (NK) activity has been examined in birds for over 30 years, but evidence that avian NK activity plays crucial roles in disease is only suggestive. In chickens, NK activity is mediated by TCR0 cells in the intestinal epithelium, but elsewhere subsets of αβ and γδ T cells (NKT cells) may be more important. There are few lectin-like NK receptor genes, located in the genomic region syntenic with the natural killer complex (NKC) as well as the major histocompatibility complex (MHC). In contrast, a huge number of Ig-like receptor genes are located in a region syntenic with the leukocyte receptor complex (LRC).
ISSN:1044-5323
1096-3618
DOI:10.1016/j.smim.2008.09.005