Superoxide Anion Production Is Increased in a Model of Genetic Hypertension: Role of the Endothelium

The hypothesis that the decreased nitric oxide (NO) availability observed in spontaneously hypertensive stroke-prone rats (SHRSP) is due to excess superoxide (O2) was examined. O2 generation, measured by lucigenin chemiluminescence, was studied in 12- to 16-week male and female Wistar-Kyoto rats (WK...

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Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1999-06, Vol.33 (6), p.1353-1358
Main Authors: Kerr, Susanne, Brosnan, M. Julia, McIntyre, Martin, Reid, John L, Dominiczak, Anna F, Hamilton, Carlene A
Format: Article
Language:English
Subjects:
Animals
Aorta, Abdominal - metabolism
Aorta, Thoracic - enzymology
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Endothelium, Vascular - physiology
Endothelium, Vascular - physiopathology
Female
Hypertension - genetics
Hypertension - metabolism
Hypertension - physiopathology
In Vitro Techniques
Male
Medical sciences
Muscle, Smooth, Vascular - metabolism
Nitric Oxide Synthase - genetics
Nitric Oxide Synthase Type III
Rats
Rats, Inbred SHR
Rats, Inbred WKY
RNA, Messenger - genetics
Sex Characteristics
Species Specificity
Superoxides - metabolism
Transcription, Genetic
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Summary:The hypothesis that the decreased nitric oxide (NO) availability observed in spontaneously hypertensive stroke-prone rats (SHRSP) is due to excess superoxide (O2) was examined. O2 generation, measured by lucigenin chemiluminescence, was studied in 12- to 16-week male and female Wistar-Kyoto rats (WKY) and SHRSP. In addition, expression of the gene encoding endothelial NO synthase, the enzyme involved in NO generation, was investigated. O2 generation was increased in male and female SHRSP (4.11 +/- 0.24 and 3.84 +/- 0.28 nmol O2 [middle dot] min [middle dot] mg respectively) compared with their WKY counterparts and was significantly higher in male than female WKY (1.22 +/- 0.08 in males and 0.8 +/- 0.08 nmol O2 [middle dot] min [middle dot] mg respectively) (SHRSP versus WKY P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.33.6.1353