Cytoskeleton cross-talk during cell motility

Cell crawling entails the co-ordinated creation and turnover of substrate contact sites that interface with the actin cytoskeleton. The initiation and maturation of contact sites involves signalling via the Rho family of small G proteins, whereas their turnover is under the additional influence of t...

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Bibliographic Details
Published in:FEBS Letters 1999-06, Vol.452 (1), p.96-99
Main Authors: Small, J.Victor, Kaverina, Irina, Krylyshkina, Olga, Rottner, Klemens
Format: Article
Language:English
Subjects:
Actin
Animals
Cell Adhesion - physiology
Cell Movement - physiology
Cell Polarity - physiology
Cytoskeleton - physiology
Microtubule
Microtubules - physiology
Rho
Signalling
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Summary:Cell crawling entails the co-ordinated creation and turnover of substrate contact sites that interface with the actin cytoskeleton. The initiation and maturation of contact sites involves signalling via the Rho family of small G proteins, whereas their turnover is under the additional influence of the microtubule cytoskeleton. By exerting relaxing effects on substrate contact assemblies in a site- and dose-specific manner, microtubules can promote both protrusion at the front and retraction at the rear, and thereby control cell polarity.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(99)00530-X