Genetic features of Mexican women predisposing to cancer of the uterine cervix

Cervical carcinoma is the most common neoplasia in Mexican women. Previous studies report association of this neoplasia with the major histocompatibility complex (MHC) antigens in Caucasians. In the present study, we compared antigen frequencies of class I and class II MHC phenotypes in patients and...

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Bibliographic Details
Published in:Human pathology 1999-06, Vol.30 (6), p.626-628
Main Authors: Silva, Beatriz, Vargas-Alarcón, Gilberto, Zúñiga-Ramos, Joaquín, Rodríguez-Reyna, Tatiana Sofía, Hernández-Martinez, Betina, Osnaya, Norma, Kofman, Susana, Torres-Lobatón, Alfonso, Granados, Julio
Format: Article
Language:English
Subjects:
Adult
Aged
Alleles
Biological and medical sciences
Carcinoma, Squamous Cell - genetics
cervical carcinoma
Female
Female genital diseases
Genes, MHC Class I - genetics
Genes, MHC Class II - genetics
Genetic Predisposition to Disease
Gynecology. Andrology. Obstetrics
HLA
Humans
major histocompatibility complex (MHC)
Medical sciences
Mexico
Middle Aged
Tropical medicine
Tumors
Uterine Cervical Neoplasms - genetics
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Summary:Cervical carcinoma is the most common neoplasia in Mexican women. Previous studies report association of this neoplasia with the major histocompatibility complex (MHC) antigens in Caucasians. In the present study, we compared antigen frequencies of class I and class II MHC phenotypes in patients and ethnically matched healthy controls. Patients had significantly increased frequencies of HLA-A2 ( PC = .000003) and HLA-DR5 ( PC = .01) as compared with healthy controls. Conversely, we found a significant decrease of HLA-DR6 ( PC = .01), HLA-DR2 ( PC = .0005) and HLA-DR1 ( PC = .0009) as compared with healthy controls. These results confirm some previous studies on HLA-associations with cervical carcinoma and reinforce the theory of independent mechanisms of MHC class I and class II genes in the etiopathogenesis of this disease.
ISSN:0046-8177
1532-8392
DOI:10.1016/S0046-8177(99)90085-0