Genetic polymorphisms in the DNA repair genes XRCC1, XRCC2 and XRCC3 and risk of breast cancer in Cyprus
Population-based studies have reported significant associations between specific genetic polymorphisms and breast cancer susceptibility. A number of studies have demonstrated that common variants of genes involved in the DNA repair pathway act as low penetrance breast cancer susceptibility alleles....
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Published in: | Breast cancer research and treatment 2008-12, Vol.112 (3), p.575-579 |
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Main Authors: | , , , , , , , , , , |
Format: | Article |
Language: | eng |
Subjects: | |
Online Access: | Get full text |
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Summary: | Population-based studies have reported significant associations between specific genetic polymorphisms and breast cancer susceptibility. A number of studies have demonstrated that common variants of genes involved in the DNA repair pathway act as low penetrance breast cancer susceptibility alleles. We aimed to investigate the association of single nucleotide polymorphisms (SNPs) in the DNA repair genes
XRCC1
,
XRCC2
and
XRCC3
and breast cancer in
MASTOS
, a population-based case–control study of 1,109 Cypriot women with breast cancer diagnosed between 40 and 70 years and 1,177 age-matched healthy controls. Five coding SNPs were genotyped including rs1799782, rs25489 and rs25487 in
XRCC1
, rs3218536 in
XRCC2
and rs861539 in
XRCC3
. Homozygous
XRCC1
280His carriers had an increased risk of breast cancer (odds ratio 4.68; 95% CI 1.01–21.7;
P
= 0.03). The
XRCC2
188His allele was associated with a marginal protective effect for breast cancer (odds ratio 0.79; 95% CI 0.62–1.00;
P
= 0.05). No significant associations were observed between the other three SNPs and breast cancer. This study suggests that genetic variation in SNPs in
XRCC1
and
XRCC2
genes may influence breast cancer susceptibility. |
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ISSN: | 0167-6806 1573-7217 |