Bone Marrow Pre-B-1 (Bomb1) : A quantitative trait locus inducing bone marrow pre-B-cell expansion in lymphoma-prone SL/Kh mice

Abnormalities of regulatory genes in early B-cell development often lead to lymphomagenesis. Our previous study showed that there is an abnormal transient expansion of bone marrow (BM) pre-B cells in lymphoma-prone SL/Kh strain mice. Such expansion is a genetic property of SL/Kh stem cells rather th...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1999-06, Vol.59 (11), p.2593-2595
Main Authors: LU, L.-M, SHIMADA, R, HIGASHI, S, ZHAOZHU ZENG, HIAI, H
Format: Article
Language:English
Subjects:
Animal tumors. Experimental tumors
Animals
Biological and medical sciences
Bone Marrow - pathology
Chemokine CXCL12
Chemokines, CXC - genetics
Crosses, Genetic
Experimental malignant blood diseases
Female
Genetic Markers
Genotype
Male
Medical sciences
Mice
Mice, Inbred Strains
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics
Sex Factors
Tumors
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Summary:Abnormalities of regulatory genes in early B-cell development often lead to lymphomagenesis. Our previous study showed that there is an abnormal transient expansion of bone marrow (BM) pre-B cells in lymphoma-prone SL/Kh strain mice. Such expansion is a genetic property of SL/Kh stem cells rather than BM microenvironments. Using the percentage of BP1+ B220+ pre-B cells in total BM lymphoid cells as a quantitative parameter, we studied the genetic control of BM pre-B cells in 159 F2 offspring of crosses between SL/Kh and NFS/N mice and 334 back-crosses to SL/Kh mice. A highly significant quantitative trait locus was identified on the distal segment of chromosome 3, showing logarithm of odds scores of 22.7 in the F2 cohort and 10.7 in back-cross mice. This quantitative trait locus, named bone marrow pre-B-1, colocalized with lymphoid enhancer factor-1, which encodes a high mobility group DNA-binding protein that is expressed in T and pre-B cells.
ISSN:0008-5472
1538-7445