Efficacy of metaphylactic florfenicol therapy during natural outbreaks of bovine respiratory disease

The efficacy of an injectable formulation of florfenicol (300 mg/mL) as metaphylactic control of naturally occurring bovine respiratory disease (BRD) was evaluated in two double-blind randomly controlled field studies on two Dutch veal calf herds (A and B). Cattle aged not older than 3 months and in...

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Bibliographic Details
Published in:Journal of veterinary pharmacology and therapeutics 2008-10, Vol.31 (5), p.479-487
Main Authors: CATRY, B, DUCHATEAU, L, VAN DE VEN, J, LAEVENS, H, OPSOMER, G, HAESEBROUCK, F, DE KRUIF, A
Format: Article
Language:English
Subjects:
animal performance
Animals
Anti-Bacterial Agents - therapeutic use
bacterial infections
Body Temperature
Body Weight
bovine respiratory disease
Cattle
Cattle Diseases - drug therapy
Cattle Diseases - epidemiology
dairy cattle
disease incidence
Disease Outbreaks - prevention & control
Disease Outbreaks - veterinary
disease prevention
dosage
drug therapy
florfenicol
health status
intensive livestock farming
Male
Mycoplasma bovis
Mycoplasma bovis - isolation & purification
Mycoplasma bovis - pathogenicity
Mycoplasma Infections - drug therapy
Mycoplasma Infections - veterinary
Netherlands
Pasteurella Infections - drug therapy
Pasteurella Infections - veterinary
Pasteurella multocida
Pasteurella multocida - isolation & purification
Pasteurella multocida - pathogenicity
pharmacology
protective effect
randomized clinical trials
Respiratory Tract Infections - drug therapy
Respiratory Tract Infections - microbiology
Respiratory Tract Infections - veterinary
subcutaneous injection
Thiamphenicol - analogs & derivatives
Thiamphenicol - therapeutic use
Tylosin - analogs & derivatives
Tylosin - therapeutic use
veal calves
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Summary:The efficacy of an injectable formulation of florfenicol (300 mg/mL) as metaphylactic control of naturally occurring bovine respiratory disease (BRD) was evaluated in two double-blind randomly controlled field studies on two Dutch veal calf herds (A and B). Cattle aged not older than 3 months and in the direct presence of calves with clinical respiratory disease were randomly allocated to treatment with 40 mg/kg florfenicol subcutaneously (s.c.) a positive control treatment (12.5 mg/kg tilmicosin p.o. twice daily for five consecutive days in herd A, and 12.5 mg/kg doxycycline p.o. twice daily for five consecutive days in herd B), or a negative control (one placebo saline s.c. administration on D0). The predominant respiratory pathogens present in pretreatment respiratory samples from affected animals were Mycoplasma bovis and Pasteurella multocida in outbreaks A and B, respectively. Metaphylactic administration of florfenicol resulted in a statistically significant weight gain, decreased rectal temperature for five consecutive days after treatment and decreased metaphylactic failure percentages compared with both positive and negative control groups. In summary, these studies demonstrated that a single s.c. injection of florfenicol is effective and practical for control of the bacterial component of BRD in veal calves.
ISSN:0140-7783
1365-2885
DOI:10.1111/j.1365-2885.2008.00981.x