Hydrogels used for cell-based drug delivery

Stem cells, progenitor cells, and lineage‐committed cells are being considered as a new generation of drug depots for the sustained release of therapeutic biomolecules. Hydrogels are often used in conjunction with the therapeutic secreting cells to provide a physical barrier to protect the cells fro...

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Bibliographic Details
Published in:Journal of Biomedical Materials Research Part B 2008-12, Vol.87A (4), p.1113-1122
Main Authors: Schmidt, John J., Rowley, Jon, Kong, Hyun Joon
Format: Article
Language:English
Subjects:
biocompatibility
Biocompatible Materials - chemistry
Biocompatible Materials - metabolism
biomolecular transport
cell viability
Cells - cytology
Cells - metabolism
Drug Carriers - chemistry
Drug Carriers - metabolism
Drug Delivery Systems - instrumentation
Drug Delivery Systems - methods
Humans
Hydrogels - chemistry
Hydrogels - metabolism
stiffness
Stress, Mechanical
therapeutic protein
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Summary:Stem cells, progenitor cells, and lineage‐committed cells are being considered as a new generation of drug depots for the sustained release of therapeutic biomolecules. Hydrogels are often used in conjunction with the therapeutic secreting cells to provide a physical barrier to protect the cells from hostile extrinsic factors. Although the hydrogels significantly improve the therapeutic efficacy of transplanted cells, there have been no successful products commercialized based on these technologies. Recently, biomaterials are increasingly designed to provide cells with both a physical barrier and an extracellular matrix to further improve the secretion of therapeutic proteins from cells. This review will discuss (1) the cell encapsulation process, (2) the immunogenicity of the encapsulating hydrogel, (3) the transport properties of the hydrogel, (4) the hydrogel mechanical properties, and will propose new strategies to improve the hydrogel and cell interaction for successful cell‐based drug delivery strategies. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res 2008
ISSN:1549-3296
1552-4965
1552-4981
DOI:10.1002/jbm.a.32287