Formulation and in vivo evaluation of ocular insert containing phenylephrine and tropicamide

A Gelfoam® based ocular device containing 1.7 mg of phenylephrine and 0.6 mg of tropicamide was formulated and evaluated for pupillary dilation in rabbits. The manufacturing procedure is fairly simple and the required excipients are inexpensive. The in vivo results show that the mydriatic response p...

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Bibliographic Details
Published in:International journal of pharmaceutics 1999-05, Vol.182 (1), p.121-126
Main Authors: Lee, Yung-Chi, Millard, Jeffrey W, J. Negvesky, Gerald, I. Butrus, Salim, H. Yalkowsky, Samuel
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Eye
Gelatin Sponge, Absorbable - administration & dosage
Gelfoam
General pharmacology
Medical sciences
Mydriasis
Mydriatic
Mydriatics - administration & dosage
Mydriatics - pharmacology
Ocular device
Ophthalmic Solutions
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Phenylephrine
Phenylephrine - administration & dosage
Phenylephrine - pharmacology
Pupil - drug effects
Rabbits
Tropicamide
Tropicamide - administration & dosage
Tropicamide - pharmacology
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Summary:A Gelfoam® based ocular device containing 1.7 mg of phenylephrine and 0.6 mg of tropicamide was formulated and evaluated for pupillary dilation in rabbits. The manufacturing procedure is fairly simple and the required excipients are inexpensive. The in vivo results show that the mydriatic response produced by the proposed device is larger and longer lasting than that produced by eyedrops with an equivalent amount of phenylephrine and tropicamide. The results reported in this study, along with those of previous studies, imply that Gelfoam® is a versatile drug carrier for either local or systemic drug delivery via the ophthalmic route.
ISSN:0378-5173
1873-3476
DOI:10.1016/S0378-5173(99)00072-1