Reliability and accuracy of fine-cut computed tomography scans to determine the status of anterior interbody fusions with metallic cages

Abstract Background context Computed tomography (CT) scan has been shown to be more accurate than radiographs in evaluating anterior interbody fusion but may still over-read the extent of fusion. Purpose To assess the reliability and accuracy of fine-cut CT scans with reconstructions in evaluating a...

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Bibliographic Details
Published in:The spine journal 2008-11, Vol.8 (6), p.998-1002
Main Authors: Carreon, Leah Y., MD, MSc, Glassman, Steven D., MD, Schwender, James D., MD, Subach, Brian R., MD, Gornet, Matthew F., MD, Ohno, Shuichiro, MD
Format: Article
Language:English
Subjects:
Adult
Aged
Anterior spine fusion
Computed tomography
Diagnostic accuracy
Diagnostic reliability
Diffusion Chambers, Culture
Female
Humans
Lumbar fusion
Lumbar Vertebrae - diagnostic imaging
Lumbar Vertebrae - surgery
Male
Middle Aged
Observer Variation
Orthopedics
Reference Standards
Reproducibility of Results
Sensitivity and Specificity
Spinal Diseases - diagnostic imaging
Spinal Diseases - surgery
Spinal Fusion
Tomography, X-Ray Computed - standards
Tomography, X-Ray Computed - statistics & numerical data
Young Adult
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Summary:Abstract Background context Computed tomography (CT) scan has been shown to be more accurate than radiographs in evaluating anterior interbody fusion but may still over-read the extent of fusion. Purpose To assess the reliability and accuracy of fine-cut CT scans with reconstructions in evaluating anterior lumbar interbody fusion (ALIF) with metallic cages using surgical exploration as the reference standard. Study design Accuracy of a diagnostic test referenced to the gold standard. Patient sample A total of 49 patients and 69 surgical levels. Outcome measures Evaluation of fine-cut CT scans for evidence of fusion with subsequent surgical exploration as the reference standard. Methods Forty-nine patients who underwent ALIF with metallic cages over 69 levels, who had a fine-cut CT scan before revision were included. Five spine surgeons unaware of the findings on surgical exploration evaluated pre-revision CT scans, classified these as fused or not; and determined the presence of a “sentinel sign” and a “posterior sentinel sign.” Kappa coefficients for interobserver reliability, sensitivity, and specificity to detect fusion were determined. Results There were 26 males and 23 females with a mean age of 43 years. There were 27 smokers. Average time from index to revision surgery was 22 months. Interobserver kappa for classification as fused or not was 0.25 with 70% to 97% sensitivity and 28% to 85% specificity. The interobserver kappa for the sentinel sign was 0.34 with 13% to 33% sensitivity and 77% to 92% specificity. The interobserver kappa for the posterior sentinel sign was 0.23 with 33% to 87% sensitivity and 56% to 90% specificity. Conclusions Raters generally overstated fusion with low specificities across raters and low consensus specificity. Overall accuracy of the posterior sentinel sign (74%) was higher than the sentinel sign (61%). The low kappa value indicates fair reliability. In patients with metallic interbody devices, surgeons should be cautious about interpreting the findings on fine-cut CT scans whether using a general assessment of the fusion, the sentinel sign, or the posterior sentinel sign.
ISSN:1529-9430
1878-1632
DOI:10.1016/j.spinee.2007.12.004