A Lymphoma Growth Inhibitor Blocks Some but Not All Prolactin-stimulated Signaling Pathways

Cytokines and hormones activate a network of intracellular signaling pathways to regulate cell division, survival and differentiation. In parallel, a series of growth inhibitory mechanisms critically restrict cell population sizes. For example, mitogens can be opposed in crowded cell cultures throug...

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Bibliographic Details
Published in:The Journal of biological chemistry 1999-05, Vol.274 (21), p.14699-14705
Main Authors: Yamashita, Hiroko, Xu, Jun, Erwin, Rebecca A., Larner, Andrew C., Rui, Hallgeir
Format: Article
Language:English
Subjects:
Animals
Calcium-Calmodulin-Dependent Protein Kinases - physiology
Cell Count
Cell Division
Culture Media, Conditioned
DNA-Binding Proteins - physiology
Genistein - pharmacology
Growth Inhibitors - physiology
Lymphoma, T-Cell
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinases
Prolactin - physiology
Rats
Signal Transduction - physiology
STAT1 Transcription Factor
STAT3 Transcription Factor
Staurosporine - pharmacology
Trans-Activators - physiology
Tumor Cells, Cultured
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Summary:Cytokines and hormones activate a network of intracellular signaling pathways to regulate cell division, survival and differentiation. In parallel, a series of growth inhibitory mechanisms critically restrict cell population sizes. For example, mitogens can be opposed in crowded cell cultures through contact-inhibition or by autocrine release of antiproliferative substances. Here, we characterize a small, heat-stable growth inhibitor secreted by a rat T lymphoma line when cultured at high cell density. Short term incubation (
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.274.21.14699