A Study of Early Pregnancy Factor Activity in the Sera of Women with Trophoblastic Tumor

PROBLEM: To detect whether or not the early pregnancy factor (EPF)‐like activity, or chaperonin 10, could be in the sera of patients with trophoblastic tumor in order to find another more efficient means to diagnose this kind of tumor. METHOD OF STUDY: The rosette inhibition assay was used to detect...

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Published in:American journal of reproductive immunology (1989) 1999-03, Vol.41 (3), p.204-208, Article 204
Main Authors: Xiaoguang, Fan, Laixi, Yan, Shunhou, Jia, Aiying, Ma, Changxin, Qiao
Format: Article
Language:English
Subjects:
Adult
Animals
Biological and medical sciences
chaperonin 10
Chaperonin 10 - blood
Chorionic Gonadotropin, beta Subunit, Human - blood
Diseases of mother, fetus and pregnancy
Early pregnancy factor
Female
Guinea Pigs
Gynecology. Andrology. Obstetrics
Humans
Medical sciences
Peptides - blood
Pregnancy
Pregnancy Proteins
Pregnancy. Fetus. Placenta
Suppressor Factors, Immunologic
Trophoblastic Neoplasms - blood
Trophoblastic Neoplasms - diagnosis
trophoblastic tumor
tumor diagnosis
tumor indicator
Uterine Neoplasms - blood
Uterine Neoplasms - diagnosis
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Summary:PROBLEM: To detect whether or not the early pregnancy factor (EPF)‐like activity, or chaperonin 10, could be in the sera of patients with trophoblastic tumor in order to find another more efficient means to diagnose this kind of tumor. METHOD OF STUDY: The rosette inhibition assay was used to detect EPF‐like activity in 216 sera, collected from patients with gestational trophoblastic tumor, including 47 sera of patients with choriocarcinoma, 68 sera of patients bearing invasive mole, and 101 sera of patients with vesicular mole. RESULTS: The accuracy of diagnosing malignant trophoblastic tumor by detecting EPF‐like activity is 91.3% (105/115), with a false positive rate of 14.58% and a false negative rate of 4.48% by this method. Furthermore, the rosette inhibition titer (RIT) values have significant difference (P < 0.001) between the sera in patients with malignant trophoblastic tumor before treatment and those after treatment. CONCLUSIONS: This study demonstrated that diagnosis of malignant trophoblastic tumor could be made with an accuracy of 91.3%) by detecting EPF‐like activity and that EPF‐like activity could be used as an indicator to distinguish benign from malignant trophoblastic tumor.
ISSN:1046-7408
8755-8920
1600-0897
2374-8192
DOI:10.1111/j.1600-0897.1999.tb00533.x