DNA structure and transcription

Regulation of transcription occurs through complex interactions of RNA polymerase and accessory proteins with specific DNA sequences and with each other. The DNA template topology influences the interaction of RNA polymerase with the promoter and its response to repressors, activators and the intrac...

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Bibliographic Details
Published in:Current opinion in microbiology 1999-04, Vol.2 (2), p.126-130
Main Authors: Dai, Xing, Rothman-Denes, Lucia B
Format: Article
Language:English
Subjects:
DNA - chemistry
Gene Expression Regulation
Nucleic Acid Conformation
Transcription, Genetic
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Summary:Regulation of transcription occurs through complex interactions of RNA polymerase and accessory proteins with specific DNA sequences and with each other. The DNA template topology influences the interaction of RNA polymerase with the promoter and its response to repressors, activators and the intracellular milieu through the formation of altered DNA structures or of nucleoprotein complexes. Recent developments on the role of DNA structures in transcription regulation are discussed.
ISSN:1369-5274
1879-0364
DOI:10.1016/S1369-5274(99)80022-8