Heat Shock Protein70: A New Marker for Subsequent Atrial Fibrillation Development?

Atrial fibrillation (AF) is a common arrhythmia, after cardiac surgery, and it is associated with a twofold increase in cardiovascular mortality and morbidity. Reperfusion injury and inflammation associated with cardiac surgery are thought to be involved in its pathogenesis. Heat shock proteins (HSP...

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Bibliographic Details
Published in:Artificial organs 2008-11, Vol.32 (11), p.846-850
Main Authors: Oc, Mehmet, Ucar, Halil Ibrahim, Pinar, Asli, Akbulut, Birkan, Oc, Bahar, Akyon, Yakut, Kanbak, Meral, Dogan, Riza
Format: Article
Language:English
Subjects:
Aged
Arrhythmia, Sinus - surgery
Atrial fibrillation
Atrial Fibrillation - blood
Atrial Fibrillation - complications
Autoantibodies - blood
Biomarkers - blood
C-Reactive Protein - analysis
Coronary Artery Bypass - adverse effects
Coronary artery bypass surgery
Coronary Artery Disease - complications
Coronary Artery Disease - surgery
Electrocardiography
Enzyme-Linked Immunosorbent Assay
Female
Heat shock protein70
HSP70 Heat-Shock Proteins - blood
Humans
Male
Middle Aged
Postoperative Complications - blood
Prospective Studies
Risk Factors
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Summary:Atrial fibrillation (AF) is a common arrhythmia, after cardiac surgery, and it is associated with a twofold increase in cardiovascular mortality and morbidity. Reperfusion injury and inflammation associated with cardiac surgery are thought to be involved in its pathogenesis. Heat shock proteins (HSPs) are a family of chaperone proteins which assist in preservation of cellular integrity by maintaining proteins in their correctly folded state. The aim of this study was to investigate pre‐postoperative heat shock protein70 (HSP70) and high‐sensitivity C‐reactive protein in serum from patients in preoperative sinus rhythm. We prospectively screened 45 consecutive patients admitted to the hospital for elective coronary artery bypass surgery (CABG). Electrocardiogram characteristics and cardiovascular risk profile were documented. Pre‐ and postoperative blood samples were collected. HSP70 value was 8.9 ± 4.8 ng/mL in Group A (study group) preoperatively and decreased to 7.7 ± 7.0 ng/mL postoperatively. In contrast, preoperative value of HSP70 was 4.2 ± 2.2 ng/mL and decreased to 2.7 ± 2.6 ng/mL postoperatively in Group B (control group). Statistical analysis showed significant difference regarding preoperative HSP70 levels in Group A compared to Group B. To our knowledge, with this study, the association of pre‐ and postoperative circulating HSP70 with postoperative AF was demonstrated for the first time.
ISSN:0160-564X
1525-1594
DOI:10.1111/j.1525-1594.2008.00640.x