Role of mixed Th1 and Th2 serum cytokines on pathogenesis and prognosis of hantavirus pulmonary syndrome

The hantavirus pulmonary syndrome (HPS) is an emerging syndrome in the Americas. The disease results from intense immune activation and changes in vascular permeability. The aim of this study was to determine the profile of serum cytokines in HPS patients looking for correlation with the clinical pa...

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Bibliographic Details
Published in:Microbes and infection 2008-08, Vol.10 (10), p.1150-1157
Main Authors: Borges, Alessandra Abel, Campos, Gelse Mazzoni, Moreli, Marcos Lázaro, Moro Souza, Ricardo Luiz, Saggioro, Fabiano Pinto, Figueiredo, Glauciane Garcia, Livonesi, Márcia Cristina, Moraes Figueiredo, Luiz Tadeu
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood Pressure
Cytokines - blood
Cytokines, Pathogenesis, Immune response
Disease Progression
Fundamental and applied biological sciences. Psychology
Hantavirus
Hantavirus - pathogenicity
Hantavirus Pulmonary Syndrome - diagnosis
Hantavirus Pulmonary Syndrome - immunology
Hantavirus Pulmonary Syndrome - pathology
Humans
Interleukins - blood
Lymphotoxin-alpha - blood
Microbiology
Miscellaneous
Nitric Oxide - blood
Prognosis
Pulmonary syndrome
Th1 Cells - immunology
Th2 Cells - immunology
Virology
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Summary:The hantavirus pulmonary syndrome (HPS) is an emerging syndrome in the Americas. The disease results from intense immune activation and changes in vascular permeability. The aim of this study was to determine the profile of serum cytokines in HPS patients looking for correlation with the clinical parameters, severity and outcome of illness. Studying 21 HPS patients, we found that IL-6 may have an important role in the pathogenesis of HPS, being associated with fatal outcome. Our results also support a mixed Th1/Th2 immune response during the course of HPS and that the magnitude of Th1 response effector cytokines is correlated to HPS severity. The decreased levels of TGF-β observed in HPS patients suggest that immunoregulatory activity could be damaged in these patients.
ISSN:1286-4579
1769-714X
DOI:10.1016/j.micinf.2008.06.006