Role of the coagulation system in allergic inflammation in the upper airways

Abstract Thrombin has been detected and demonstrated to play a role in the airways of patients with bronchial asthma, but its role in the upper airways including during allergic rhinitis is unknown. This study was conducted to explore whether thrombin is presence in the upper airways and, if so, whe...

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Published in:Clinical immunology (Orlando, Fla.) Fla.), 2008-11, Vol.129 (2), p.365-371
Main Authors: Shimizu, Shino, Shimizu, Takeshi, Morser, John, Kobayashi, Tetsu, Yamaguchi, Aiko, Qin, Liqiang, Toda, Masaaki, D'Alessandro-Gabazza, Corina, Maruyama, Takaya, Takagi, Takehiro, Yano, Yutaka, Sumida, Yasuhiro, Hayashi, Tatsuya, Takei, Yoshiyuki, Taguchi, Osamu, Suzuki, Koji, Gabazza, Esteban C
Format: Article
Language:English
Subjects:
Allergy
Allergy and Immunology
Animals
Biological and medical sciences
Blood Coagulation
Cells, Cultured
Coagulation
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Inflammation
Male
Mucin 5AC
Mucins - secretion
Protein C - physiology
Rats
Rats, Inbred F344
Receptor, PAR-1 - physiology
Rhinitis, Allergic, Perennial - etiology
Rhinitis, Allergic, Seasonal - etiology
Thrombin - physiology
Thromboplastin - analysis
Thromboplastin - physiology
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Summary:Abstract Thrombin has been detected and demonstrated to play a role in the airways of patients with bronchial asthma, but its role in the upper airways including during allergic rhinitis is unknown. This study was conducted to explore whether thrombin is presence in the upper airways and, if so, whether it affects mucin secretion. Fifteen patients with allergic rhinitis were enrolled in the clinical study; primary nasal septum epithelial cells and normal bronchial epithelial cells were used for in vitro evaluation, and rats as animal models. Significant concentrations of thrombin were found in nasal secretion after allergic provocation in allergic patients, and thrombin and its agonistic receptor peptide induced significant secretion of mucin in primary nasal cells and normal bronchial epithelial cells as compared to non-stimulated cells. Increased mucosubstance secretion in septum epithelial cells was also induced after nasal instillation of thrombin in rats. Further, the anticoagulant, activated protein C, significantly inhibited thrombin-induced mucin secretion from septum epithelial cells in rats. The results of this study suggest that activation of the coagulation system occurs during the allergic response and that thrombin plays a crucial role in the regulation of mucin production in the upper airways.
ISSN:1521-6616
0090-1229
1521-7035
DOI:10.1016/j.clim.2008.07.020