Plasma homocysteine, vitamin B12 and folate levels in hydatidiform moles and histopathological subtypes

Objective To investigate the association of mole hydatidiform with plasma homocysteine, vitamin B 12 , and folate levels. Methods Sixty-eight patients diagnosed with mole hydatidiform at our clinic between February and October 2007 were assessed in a case-control study. Plasma homocysteine, vitamin...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2008-12, Vol.278 (6), p.531-534
Main Authors: Kokanalı, M. Kuntay, Öztürkkan, Demet, Ünsal, Naim, Möroy, Perran, Güngör, Tayfun, Mollamahmutoğlu, Leyla
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
Endocrinology
Female
Folic Acid - blood
Gynecology
Health risk assessment
Homocysteine
Homocysteine - blood
Human Genetics
Humans
Hydatidiform Mole - blood
Hydatidiform Mole - pathology
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Original Article
Plasma
Pregnancy
Statistics, Nonparametric
Uterine Neoplasms - blood
Uterine Neoplasms - pathology
Vitamin B
Vitamin B 12 - blood
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Summary:Objective To investigate the association of mole hydatidiform with plasma homocysteine, vitamin B 12 , and folate levels. Methods Sixty-eight patients diagnosed with mole hydatidiform at our clinic between February and October 2007 were assessed in a case-control study. Plasma homocysteine, vitamin B 12 , and folate levels, taken before evacuation of patients with hydatidiform mole, were compared with the results of 100 healthy normal pregnants of first trimester; and also plasma homocysteine, vitamin B 12 , and folate levels were compared according to histopathological types of mole hydatidiforms. SPSS 14.0 package program was used to analyze the data. Logarithmic transformation was applied for variables. Parameters were expressed as mean ± standard deviation. Results The mean of plasma homocysteine levels was higher in molar group (0.8 ± 0.13) than in normal pregnant group (0.7 ± 0.13) and the difference was statistically significant ( P 
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-008-0637-0