High prevalence of Neisseria meningitidis hypervirulent lineages and emergence of W135:P1.5,2:ST-11 clone in Southern Brazil

Summary Objectives The aim of this study was to characterize Neisseria meningitidis strains causing invasive disease in Rio Grande do Sul (RS), during 2003–2005, monitoring the occurrence of hypervirulent lineages, as well as to determine the diversity of PorA VR types for the corresponding isolates...

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Bibliographic Details
Published in:The Journal of infection 2008-10, Vol.57 (4), p.324-331
Main Authors: Weidlich, Luciana, Baethgen, Ludmila F, Mayer, Leonard W, Moraes, Camile, Klein, Cecília C, Nunes, Luciana S, Rios, Sílvia da S, Kmetzsch, Claudete I, Rossetti, Maria L.R, Zaha, Arnaldo
Format: Article
Language:English
Subjects:
Bacterial diseases
Bacterial diseases of the nervous system. Bacterial myositis
Bacterial Typing Techniques
Biological and medical sciences
Brazil - epidemiology
Child, Preschool
DNA, Bacterial - genetics
Epidemiology
General aspects
Human bacterial diseases
Humans
Hypervirulent lineages
Infant
Infectious Disease
Infectious diseases
Medical sciences
Meningitis, Meningococcal - epidemiology
Meningitis, Meningococcal - microbiology
Meningococcal Infections - epidemiology
Meningococcal Infections - microbiology
Molecular Epidemiology
Neisseria meningitidis
Neisseria meningitidis - classification
Neisseria meningitidis - genetics
Neisseria meningitidis - isolation & purification
Neisseria meningitidis - pathogenicity
Neisseria meningitidis, Serogroup B - classification
Neisseria meningitidis, Serogroup B - genetics
Neisseria meningitidis, Serogroup B - isolation & purification
Neisseria meningitidis, Serogroup C - classification
Neisseria meningitidis, Serogroup C - genetics
Neisseria meningitidis, Serogroup C - isolation & purification
Neisseria meningitidis, Serogroup W-135 - classification
Neisseria meningitidis, Serogroup W-135 - genetics
Neisseria meningitidis, Serogroup W-135 - isolation & purification
Population Surveillance
PorA VR types
Porins - genetics
Prevalence
Sequence Analysis, DNA
Serogroup B vaccine
Serotyping
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Summary:Summary Objectives The aim of this study was to characterize Neisseria meningitidis strains causing invasive disease in Rio Grande do Sul (RS), during 2003–2005, monitoring the occurrence of hypervirulent lineages, as well as to determine the diversity of PorA VR types for the corresponding isolates and clinical specimens. Methods Isolates and clinical specimens were characterized by MLST and PorA VR typing. Results This study demonstrated high prevalence of some hypervirulent lineages and emergence of new ones, including the emergence of lineages W135:P1.5,2:ST-11 complex, and C:P1.22,14-6:ST-103 complex. These lineages are probably responsible for the increasing incidence of serogroups C and W135, despite the overall decrease in serogroup B cases during the period. The most prevalent complex was serogroup B ST-32/ET-5 complex. The most prevalent PorA types found for serogroup B were P1.19,15, P1.7,16, and P1.18-1,3, representing a different distribution of PorA types compared to other states of Brazil. Conclusions This study highlights the importance of monitoring each population, even within the same country. The different distribution of PorA VR types in RS has implications in vaccine design and efficacy. Detailed and accurate meningococcal characterization is an important element in studies of meningococcal epidemiology, population biology, and evolution and provides information for the design of control strategies.
ISSN:0163-4453
1532-2742
DOI:10.1016/j.jinf.2008.07.014