Results of in vitro fertilization in Italy after the introduction of a new law

Objective To investigate the consequences of a law introduced in Italy in 2004 that forbids the fertilization or injection of more than three oocytes for assisted reproduction and does not allow any embryo selection or cryopreservation. Design Retrospective observational analysis. Setting Subfertile...

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Bibliographic Details
Published in:Fertility and sterility 2008-10, Vol.90 (4), p.1081-1086
Main Authors: Levi Setti, Paolo Emanuele, M.D, Albani, Elena, B.Sc, Novara, Paola, B.Sc, Cesana, Amalia, B.Sc, Negri, Luciano, M.D
Format: Article
Language:English
Subjects:
Adult
Age Distribution
Assisted reproduction
Biological and medical sciences
Female
Fertilization in Vitro - legislation & jurisprudence
Fertilization in Vitro - statistics & numerical data
Gynecology. Andrology. Obstetrics
Humans
Incidence
Infertility - epidemiology
Infertility - therapy
Internal Medicine
Italy - epidemiology
law
legislation
Medical sciences
Obstetrics and Gynecology
Pregnancy
Pregnancy Outcome - epidemiology
pregnancy rate
reproductive migration
Treatment Outcome
Triplets
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Summary:Objective To investigate the consequences of a law introduced in Italy in 2004 that forbids the fertilization or injection of more than three oocytes for assisted reproduction and does not allow any embryo selection or cryopreservation. Design Retrospective observational analysis. Setting Subfertile patients enrolled in an assisted reproduction program. Patient(s) Before the introduction of the law there were 1,179 cycles and after its enactment there were 1,860 cycles in 1,619 subfertile couples. Intervention(s) Ovarian stimulation for IVF/intracytoplasmic sperm injection (ICSI) attempts. Main Outcome Measure(s) Pregnancy and implantation rate. Result(s) Pregnancy rates (PR) per cycle (24.34% vs. 23.11%), per retrieval (28.64% vs. 25.65%), per transfer (31.37% vs. 27.74%), and the take-home babies per started cycle (19.1% vs. 18%) was not significantly different between the two periods. After introduction of the law, the PR significantly decreased in patients whose total motile sperm count was
ISSN:0015-0282
1556-5653
DOI:10.1016/j.fertnstert.2007.07.1339