Amygdalar neuropeptide Y Y1 receptors mediate the anxiolytic-like actions of neuropeptide Y in the social interaction test

The effects of intra-amygdalar neuropeptide Y infusions were assessed in rats using the social interaction test. Neuropeptide Y administered into the central nucleus of the amygdala did not alter behavior, while injections into the basolateral nucleus of the amygdala produced an increased social int...

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Bibliographic Details
Published in:European journal of pharmacology 1999-03, Vol.368 (2-3), p.143-147
Main Authors: SAJDYK, T. J, VANDERGRIFF, M. G, GEHLERT, D. R
Format: Article
Language:English
Subjects:
Amygdala - drug effects
Amygdala - metabolism
Animal Communication
Animals
Anti-Anxiety Agents - pharmacology
Arginine - analogs & derivatives
Arginine - chemistry
Arginine - pharmacology
Behavior, Animal - drug effects
Behavioral psychophysiology
Biological and medical sciences
Dose-Response Relationship, Drug
Fundamental and applied biological sciences. Psychology
Male
Miscellaneous
Neuropeptide Y - pharmacology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Rats, Wistar
Receptors, Neuropeptide Y - antagonists & inhibitors
Receptors, Neuropeptide Y - physiology
Social Behavior
Stereoisomerism
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Summary:The effects of intra-amygdalar neuropeptide Y infusions were assessed in rats using the social interaction test. Neuropeptide Y administered into the central nucleus of the amygdala did not alter behavior, while injections into the basolateral nucleus of the amygdala produced an increased social interaction time. Furthermore, the anxiolytic-like effect was antagonized by co-administration of the potent neuropeptide Y Y1 receptor antagonist ((R)-N-[[4-(aminocarbonylaminomethyl)-phenyl]methyl]-N2-(diphen ylacetyl)-argininamide trifluoroacetate) 3304, but not with the inactive enantiomer ((R)-N-[[4-(aminocarbonylaminomethyl)-phenyl]methyl]-N2-(diphen ylacetyl)-argininamide trifluoroacetate) 3457. Therefore, neuropeptide Y produces an anxiolytic-like effect in the social interaction test through neuropetide Y Y1 receptors located in the basolateral amygdala.
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(99)00018-7