Von Willebrand factor could be an index of endothelial dysfunction in patients with cirrhosis: relationship to degree of liver failure and nitric oxide levels

Background/Aims: The aim of this study was to evaluate the relationship between plasma levels of von Willebrand factor (vWF), a marker of endothelial cell activation, and nitric oxide, a powerful vasodilator synthesized by endothelial cells, in 27 patients with cirrhosis at different stages of the d...

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Bibliographic Details
Published in:Journal of hepatology 1999-03, Vol.30 (3), p.451-455
Main Authors: Albornoz, Liliana, Alvarez, Daniel, Otaso, Juan Carlos, Gadano, Adrián, Salviú, Julieta, Gerona, Solange, Sorroche, Patricia, Villamil, Alejandra, Mastai, Ricardo
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biomarkers
Cirrhosis
Endothelium, Vascular - metabolism
Endothelium, Vascular - physiopathology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Hemodynamics
Humans
Liver Cirrhosis - blood
Liver Cirrhosis - pathology
Liver Cirrhosis - physiopathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Nitric oxide
Nitric Oxide - blood
Other diseases. Semiology
Tropical medicine
Von Willebrand Factor
von Willebrand Factor - metabolism
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Summary:Background/Aims: The aim of this study was to evaluate the relationship between plasma levels of von Willebrand factor (vWF), a marker of endothelial cell activation, and nitric oxide, a powerful vasodilator synthesized by endothelial cells, in 27 patients with cirrhosis at different stages of the disease. These results were compared with those of age-matched normal, healthy subjects ( n=10). Methods: vWF:antigen was measured by electro-immunodiffusion test and serum nitrite and nitrate levels, the stable end products of nitric oxide metabolism, were determined by an enzymatic procedure. Results: vWF:antigen and nitrite/nitrate levels were significantly higher in cirrhotic patients (367±185% and 29.3±10.8 μmol/l) than in healthy subjects (92±20% and 19.2±8.3 μmol/l, p
ISSN:0168-8278
1600-0641
DOI:10.1016/S0168-8278(99)80104-4