Suprasellar ganglioglioma with unusual diffuse involvement of the entire optico-chiasmal hypothalamic pathway

Gangliogliomas (GG) are mixed glioneuronal tumors of the central nervous system (CNS), occurring mostly in the pediatric population, with common sites being temporal lobes and less commonly in the frontal and parietal lobes. We report a case of a 7-year-old child who presented with bilateral visual...

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Bibliographic Details
Published in:Journal of cancer research and therapeutics 2008-07, Vol.4 (3), p.140-143
Main Authors: Jalali, Rakesh, Deopujari, Chandrashekar E, Bhutani, Ritu, Suhas, U, Rajasekharan, Preetha, Kane, Shubdha V, Gupta, Tejpal
Format: Article
Language:English
Subjects:
Antineoplastic Agents - therapeutic use
Brain Neoplasms - metabolism
Brain Neoplasms - pathology
Brain Neoplasms - therapy
Case studies
Chiasmal hypothalamic tumors
Child
Combined Modality Therapy
Complications and side effects
Development and progression
Diagnosis
Female
ganglioglioma
Ganglioglioma - metabolism
Ganglioglioma - pathology
Ganglioglioma - therapy
Gliomas
Health aspects
histopathology
Humans
Hypothalamus - pathology
imaging
Immunohistochemistry
Magnetic Resonance Imaging
Neurosurgical Procedures
optic apparatus
Optic Chiasm - pathology
Optic nerve
Radiosurgery
Radiotherapy, Conformal
Visual Pathways - pathology
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Summary:Gangliogliomas (GG) are mixed glioneuronal tumors of the central nervous system (CNS), occurring mostly in the pediatric population, with common sites being temporal lobes and less commonly in the frontal and parietal lobes. We report a case of a 7-year-old child who presented with bilateral visual defects for 6 months. Magnetic resonance imaging (MRI) of the brain revealed an intensely enhancing mass lesion with calcification in the sellar and suprasellar region involving the optic chiasm and the left optic nerve. The mass showed almost bilaterally symmetrical diffuse spread along the optic tracts posteriorly and hypothalamus, temporal lobes, thalami and the basal ganglia. The lesion was radiologically indistinguishable from chiasmatic astrocytoma or a germ cell tumor but histopathological features were of a ganglioglioma. While a few optic apparatus gangliogliomas have been reported in the literature, such widespread diffuse involvement of the entire optico-chiasmal hypothalamic pathway is unusual.
ISSN:0973-1482
1998-4138
DOI:10.4103/0973-1482.43151