Phenotypic and genotypic investigations of a healthy volunteer deficient in the conversion of losartan to its active metabolite E-3174

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Bibliographic Details
Published in:Clinical pharmacology and therapeutics 1999-03, Vol.65 (3), p.348-352
Main Authors: McCrea, Jacqueline B., Cribb, Alastair, Rushmore, Tom, Osborne, Barbara, Gillen, Lisa, Lo, Man‐Wai, Waldman, Scott, Bjornsson, Thorir, Spielberg, Stephen, Goldberg, Michael R.
Format: Article
Language:English
Subjects:
Adult
Alleles
Anti-Arrhythmia Agents - metabolism
Antihypertensive agents
Antihypertensive Agents - metabolism
Aryl Hydrocarbon Hydroxylases
Biological and medical sciences
Cardiovascular system
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System - genetics
Genotype
Humans
Imidazoles - metabolism
Losartan - metabolism
Male
Medical sciences
Mixed Function Oxygenases - genetics
Pharmacology. Drug treatments
Phenotype
Reference Values
Steroid 16-alpha-Hydroxylase
Steroid Hydroxylases - genetics
Tetrazoles - metabolism
Volunteers
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Summary:
ISSN:0009-9236
1532-6535
DOI:10.1016/S0009-9236(99)70114-1