role of macrophage migration inhibitory factor on glucose metabolism and diabetes

Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine involved in many inflammatory reactions and disorders, and it has become evident that it also affects glucose homeostasis. The protein is produced by pancreatic beta cells and can promote the release of insulin. It also modul...

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Bibliographic Details
Published in:Diabetologia 2008-11, Vol.51 (11), p.1937-1946
Main Authors: Toso, C, Emamaullee, J. A, Merani, S, Shapiro, A. M. J
Format: Article
Language:English
Subjects:
Adaptive immunity
Apoptosis
Biological and medical sciences
Blood Glucose - metabolism
Cell adhesion & migration
Cytokine
Cytokines
Diabetes
Diabetes Mellitus - blood
Diabetes Mellitus - metabolism
Diabetes Mellitus - physiopathology
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - physiopathology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Glucose
Glucose - metabolism
Homeostasis
Human Physiology
Humans
Inflammation
Inflammation - physiopathology
Insulin resistance
Internal Medicine
Islet transplantation
Kinases
Lymphocytes
Macrophage Migration-Inhibitory Factors - physiology
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolism
Physiology
Proteins
Review
Signal transduction
Transplants & implants
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Summary:Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine involved in many inflammatory reactions and disorders, and it has become evident that it also affects glucose homeostasis. The protein is produced by pancreatic beta cells and can promote the release of insulin. It also modulates glucose uptake, glycolysis and insulin resistance in insulin target cells such as the adipocyte, myocyte and cardiomyocyte. Possessing both immunological and endocrinological properties, MIF has been associated with the development of type 1 and type 2 diabetes, and it may be important in the setting of islet transplantation. The present review summarises our current knowledge, based on clinical and research data, on the impact of MIF on both physiological and pathological aspects of glucose metabolism.
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-008-1063-3