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In Vivo UVA-1 and UVB Irradiation Differentially Perturbs the Antigen-Presenting Function of Human Epidermal Langerhans Cells
Ultraviolet B (UVB, 290–320 nm) radiation is known to suppress the immune function of epidermal Langerhans cells. We have recently described that in vitro UVB irradiation perturbs the antigen-presenting cell function of Langerhans cells by inhibiting their expression of functional B7 costimulatory m...
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| Published in: | Journal of investigative dermatology 1999-03, Vol.112 (3), p.322-325 |
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| container_end_page | 325 |
| container_issue | 3 |
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| container_title | Journal of investigative dermatology |
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| creator | Dittmar, Henning C. Weiss, Johannes M. Termeer, Christian C. Denfeld, Ralf W. Schöpf, Erwin Simon, Jan C. Wanner, Marcus B. Skov, Lone Barker, Jonathan Nwn Baadsgaard, Ole |
| description | Ultraviolet B (UVB, 290–320 nm) radiation is known to suppress the immune function of epidermal Langerhans cells. We have recently described that in vitro UVB irradiation perturbs the antigen-presenting cell function of Langerhans cells by inhibiting their expression of functional B7 costimulatory molecules (B7–1, B7–2). The aim of this study was to determine wavelength-specific UV effects on Langerhans cells function in vivo, specifically UVB and UVA-1. To address this issue, volunteers were irradiated on the sunprotected volar aspects of their forearms with 3 × minimal erythema dose of UVB (Philips TL-12) and UVA-1 (UVASUN 5000 Mutzhaas). Langerhans cells were isolated from suction blister roofs immediately following irradiation. Langerhans cells isolated from UVB- but not from UVA-1-irradiated skin failed to activate naïve resting allogeneic T cells (mixed epidermal cell leukocyte reaction) or primed tetanus toxoid reactive autologous T cells. Langerhans cells isolated from sham-irradiated or UVA-1-irradiated skin strongly upregulated B7–2 molecules during short-term tissue culture. By contrast, Langerhans cells from UVB-irradiated skin did not upregulate B7–2 molecules. Furthermore, exogenous stimulation of the B7 pathway by anti-CD28 stimulatory monoclonal antibodies restored the capacity of UVB-irradiated Langerhans cells to activate both alloreactive and tetanus toxoid-reactive T cells, implying suppressed antigen-presenting cell activities and perturbed B7 expression of Langerhans cells isolated from UVB-irradiated skin are related. Those studies demonstrate that in vivo UVB, but not UVA-1, interferes with the activation-dependent upregulation of B7 molecules on Langerhans cells, which in turn is of functional relevance for the perturbed antigen-presenting cell function of Langerhans cells within UVB- but not UVA-1-irradiated skin. |
| doi_str_mv | 10.1046/j.1523-1747.1999.00527.x |
| format | article |
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We have recently described that in vitro UVB irradiation perturbs the antigen-presenting cell function of Langerhans cells by inhibiting their expression of functional B7 costimulatory molecules (B7–1, B7–2). The aim of this study was to determine wavelength-specific UV effects on Langerhans cells function in vivo, specifically UVB and UVA-1. To address this issue, volunteers were irradiated on the sunprotected volar aspects of their forearms with 3 × minimal erythema dose of UVB (Philips TL-12) and UVA-1 (UVASUN 5000 Mutzhaas). Langerhans cells were isolated from suction blister roofs immediately following irradiation. Langerhans cells isolated from UVB- but not from UVA-1-irradiated skin failed to activate naïve resting allogeneic T cells (mixed epidermal cell leukocyte reaction) or primed tetanus toxoid reactive autologous T cells. Langerhans cells isolated from sham-irradiated or UVA-1-irradiated skin strongly upregulated B7–2 molecules during short-term tissue culture. By contrast, Langerhans cells from UVB-irradiated skin did not upregulate B7–2 molecules. Furthermore, exogenous stimulation of the B7 pathway by anti-CD28 stimulatory monoclonal antibodies restored the capacity of UVB-irradiated Langerhans cells to activate both alloreactive and tetanus toxoid-reactive T cells, implying suppressed antigen-presenting cell activities and perturbed B7 expression of Langerhans cells isolated from UVB-irradiated skin are related. Those studies demonstrate that in vivo UVB, but not UVA-1, interferes with the activation-dependent upregulation of B7 molecules on Langerhans cells, which in turn is of functional relevance for the perturbed antigen-presenting cell function of Langerhans cells within UVB- but not UVA-1-irradiated skin.</description><identifier>ISSN: 0022-202X</identifier><identifier>EISSN: 1523-1747</identifier><identifier>DOI: 10.1046/j.1523-1747.1999.00527.x</identifier><identifier>PMID: 10084309</identifier><identifier>CODEN: JIDEAE</identifier><language>eng</language><publisher>Danvers, MA: Elsevier Inc</publisher><subject>Antigen Presentation - radiation effects ; Antigen-Presenting Cells - metabolism ; Antigen-Presenting Cells - physiology ; Antigen-Presenting Cells - radiation effects ; Antigens, CD - metabolism ; B7-2 Antigen ; Biological and medical sciences ; Biological effects of radiation ; CD28 ; CD80 ; CD86 ; Epidermis - radiation effects ; Fundamental and applied biological sciences. Psychology ; Humans ; Langerhans Cells - metabolism ; Langerhans Cells - physiology ; Langerhans Cells - radiation effects ; Membrane Glycoproteins - metabolism ; Non ionizing radiations. Hertzian waves. Biooptics ; Skin - cytology ; Skin - metabolism ; Skin - radiation effects ; tetanus toxoid ; Tissues, organs and organisms biophysics ; Ultraviolet Rays</subject><ispartof>Journal of investigative dermatology, 1999-03, Vol.112 (3), p.322-325</ispartof><rights>1999 The Society for Investigative Dermatology, Inc</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c566t-9f7cc30617383882a54899621cec2ecf4fafb1fe4db3334807cf708ffadfe67a3</citedby><cites>FETCH-LOGICAL-c566t-9f7cc30617383882a54899621cec2ecf4fafb1fe4db3334807cf708ffadfe67a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1706895$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10084309$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dittmar, Henning C.</creatorcontrib><creatorcontrib>Weiss, Johannes M.</creatorcontrib><creatorcontrib>Termeer, Christian C.</creatorcontrib><creatorcontrib>Denfeld, Ralf W.</creatorcontrib><creatorcontrib>Schöpf, Erwin</creatorcontrib><creatorcontrib>Simon, Jan C.</creatorcontrib><creatorcontrib>Wanner, Marcus B.</creatorcontrib><creatorcontrib>Skov, Lone</creatorcontrib><creatorcontrib>Barker, Jonathan Nwn</creatorcontrib><creatorcontrib>Baadsgaard, Ole</creatorcontrib><title>In Vivo UVA-1 and UVB Irradiation Differentially Perturbs the Antigen-Presenting Function of Human Epidermal Langerhans Cells</title><title>Journal of investigative dermatology</title><addtitle>J Invest Dermatol</addtitle><description>Ultraviolet B (UVB, 290–320 nm) radiation is known to suppress the immune function of epidermal Langerhans cells. We have recently described that in vitro UVB irradiation perturbs the antigen-presenting cell function of Langerhans cells by inhibiting their expression of functional B7 costimulatory molecules (B7–1, B7–2). The aim of this study was to determine wavelength-specific UV effects on Langerhans cells function in vivo, specifically UVB and UVA-1. To address this issue, volunteers were irradiated on the sunprotected volar aspects of their forearms with 3 × minimal erythema dose of UVB (Philips TL-12) and UVA-1 (UVASUN 5000 Mutzhaas). Langerhans cells were isolated from suction blister roofs immediately following irradiation. Langerhans cells isolated from UVB- but not from UVA-1-irradiated skin failed to activate naïve resting allogeneic T cells (mixed epidermal cell leukocyte reaction) or primed tetanus toxoid reactive autologous T cells. Langerhans cells isolated from sham-irradiated or UVA-1-irradiated skin strongly upregulated B7–2 molecules during short-term tissue culture. By contrast, Langerhans cells from UVB-irradiated skin did not upregulate B7–2 molecules. Furthermore, exogenous stimulation of the B7 pathway by anti-CD28 stimulatory monoclonal antibodies restored the capacity of UVB-irradiated Langerhans cells to activate both alloreactive and tetanus toxoid-reactive T cells, implying suppressed antigen-presenting cell activities and perturbed B7 expression of Langerhans cells isolated from UVB-irradiated skin are related. Those studies demonstrate that in vivo UVB, but not UVA-1, interferes with the activation-dependent upregulation of B7 molecules on Langerhans cells, which in turn is of functional relevance for the perturbed antigen-presenting cell function of Langerhans cells within UVB- but not UVA-1-irradiated skin.</description><subject>Antigen Presentation - radiation effects</subject><subject>Antigen-Presenting Cells - metabolism</subject><subject>Antigen-Presenting Cells - physiology</subject><subject>Antigen-Presenting Cells - radiation effects</subject><subject>Antigens, CD - metabolism</subject><subject>B7-2 Antigen</subject><subject>Biological and medical sciences</subject><subject>Biological effects of radiation</subject><subject>CD28</subject><subject>CD80</subject><subject>CD86</subject><subject>Epidermis - radiation effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Langerhans Cells - metabolism</subject><subject>Langerhans Cells - physiology</subject><subject>Langerhans Cells - radiation effects</subject><subject>Membrane Glycoproteins - metabolism</subject><subject>Non ionizing radiations. Hertzian waves. Biooptics</subject><subject>Skin - cytology</subject><subject>Skin - metabolism</subject><subject>Skin - radiation effects</subject><subject>tetanus toxoid</subject><subject>Tissues, organs and organisms biophysics</subject><subject>Ultraviolet Rays</subject><issn>0022-202X</issn><issn>1523-1747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqFkM1u3CAURlHVqpmmfYRWLKru7IKxMSwnk7-RRmoWTdQdYvBlwsjGU7CjZNF3L45HSXddgbjn4346CGFKckpK_n2f06pgGa3LOqdSypyQqqjzxzdo8TJ4ixaEFEVWkOLXCfoQ454QystKvEcnlBBRMiIX6M_a4zv30OPbu2VGsfZNup3hdQi6cXpwvcfnzloI4Aen2_YJ30AYxrCNeLgHvEyvO_DZTYA4EX6HL0dvnnO9xddjpz2-OLgGQqdbvNF-B-Fe-4hX0LbxI3pndRvh0_E8RbeXFz9X19nmx9V6tdxkpuJ8yKStjWGE05oJJkShq1JIyQtqwBRgbGm13VILZbNljJWC1MbWRFirGwu81uwUfZv_PYT-9whxUJ2LJjXQHvoxKi45S15pAsUMmtDHGMCqQ3CdDk-KEjWpV3s1GVaTYTWpV8_q1WOKfjnuGLcdNP8EZ9cJ-HoEdDS6tUF74-IrVxMuZJWwzzPmdfIML_OKE1KyqeLZPIck7MFBUNE48AYaF8AMqund_8v-BXsCrPY</recordid><startdate>19990301</startdate><enddate>19990301</enddate><creator>Dittmar, Henning C.</creator><creator>Weiss, Johannes M.</creator><creator>Termeer, Christian C.</creator><creator>Denfeld, Ralf W.</creator><creator>Schöpf, Erwin</creator><creator>Simon, Jan C.</creator><creator>Wanner, Marcus B.</creator><creator>Skov, Lone</creator><creator>Barker, Jonathan Nwn</creator><creator>Baadsgaard, Ole</creator><general>Elsevier Inc</general><general>Nature Publishing</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990301</creationdate><title>In Vivo UVA-1 and UVB Irradiation Differentially Perturbs the Antigen-Presenting Function of Human Epidermal Langerhans Cells</title><author>Dittmar, Henning C. ; Weiss, Johannes M. ; Termeer, Christian C. ; Denfeld, Ralf W. ; Schöpf, Erwin ; Simon, Jan C. ; Wanner, Marcus B. ; Skov, Lone ; Barker, Jonathan Nwn ; Baadsgaard, Ole</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c566t-9f7cc30617383882a54899621cec2ecf4fafb1fe4db3334807cf708ffadfe67a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Antigen Presentation - radiation effects</topic><topic>Antigen-Presenting Cells - metabolism</topic><topic>Antigen-Presenting Cells - physiology</topic><topic>Antigen-Presenting Cells - radiation effects</topic><topic>Antigens, CD - metabolism</topic><topic>B7-2 Antigen</topic><topic>Biological and medical sciences</topic><topic>Biological effects of radiation</topic><topic>CD28</topic><topic>CD80</topic><topic>CD86</topic><topic>Epidermis - radiation effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Langerhans Cells - metabolism</topic><topic>Langerhans Cells - physiology</topic><topic>Langerhans Cells - radiation effects</topic><topic>Membrane Glycoproteins - metabolism</topic><topic>Non ionizing radiations. Hertzian waves. 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We have recently described that in vitro UVB irradiation perturbs the antigen-presenting cell function of Langerhans cells by inhibiting their expression of functional B7 costimulatory molecules (B7–1, B7–2). The aim of this study was to determine wavelength-specific UV effects on Langerhans cells function in vivo, specifically UVB and UVA-1. To address this issue, volunteers were irradiated on the sunprotected volar aspects of their forearms with 3 × minimal erythema dose of UVB (Philips TL-12) and UVA-1 (UVASUN 5000 Mutzhaas). Langerhans cells were isolated from suction blister roofs immediately following irradiation. Langerhans cells isolated from UVB- but not from UVA-1-irradiated skin failed to activate naïve resting allogeneic T cells (mixed epidermal cell leukocyte reaction) or primed tetanus toxoid reactive autologous T cells. Langerhans cells isolated from sham-irradiated or UVA-1-irradiated skin strongly upregulated B7–2 molecules during short-term tissue culture. By contrast, Langerhans cells from UVB-irradiated skin did not upregulate B7–2 molecules. Furthermore, exogenous stimulation of the B7 pathway by anti-CD28 stimulatory monoclonal antibodies restored the capacity of UVB-irradiated Langerhans cells to activate both alloreactive and tetanus toxoid-reactive T cells, implying suppressed antigen-presenting cell activities and perturbed B7 expression of Langerhans cells isolated from UVB-irradiated skin are related. Those studies demonstrate that in vivo UVB, but not UVA-1, interferes with the activation-dependent upregulation of B7 molecules on Langerhans cells, which in turn is of functional relevance for the perturbed antigen-presenting cell function of Langerhans cells within UVB- but not UVA-1-irradiated skin.</abstract><cop>Danvers, MA</cop><pub>Elsevier Inc</pub><pmid>10084309</pmid><doi>10.1046/j.1523-1747.1999.00527.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of investigative dermatology, 1999-03, Vol.112 (3), p.322-325 |
| issn | 0022-202X 1523-1747 |
| language | eng |
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| source | BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS |
| subjects | Antigen Presentation - radiation effects Antigen-Presenting Cells - metabolism Antigen-Presenting Cells - physiology Antigen-Presenting Cells - radiation effects Antigens, CD - metabolism B7-2 Antigen Biological and medical sciences Biological effects of radiation CD28 CD80 CD86 Epidermis - radiation effects Fundamental and applied biological sciences. Psychology Humans Langerhans Cells - metabolism Langerhans Cells - physiology Langerhans Cells - radiation effects Membrane Glycoproteins - metabolism Non ionizing radiations. Hertzian waves. Biooptics Skin - cytology Skin - metabolism Skin - radiation effects tetanus toxoid Tissues, organs and organisms biophysics Ultraviolet Rays |
| title | In Vivo UVA-1 and UVB Irradiation Differentially Perturbs the Antigen-Presenting Function of Human Epidermal Langerhans Cells |
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