Antioxidant and Antiinflammatory Activities of Anthocyanins and Their Aglycon, Cyanidin, from Tart Cherries

The anthocyanins (1−3) and cyanidin isolated from tart cherries exhibited in vitro antioxidant and antiinflammatory activities comparable to commercial products. The inhibition of lipid peroxidation of anthocyanins 1−3 and their aglycon, cyanidin, were 39, 70, 75, and 57%, respectively, at 2-mM conc...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1999-02, Vol.62 (2), p.294-296
Main Authors: Wang, Haibo, Nair, Muraleedharan G, Strasburg, Gale M, Chang, Yu-Chen, Booren, Alden M, Gray, J. Ian, DeWitt, David L
Format: Article
Language:English
Subjects:
Animals
anthocyanins
Anthocyanins - chemistry
Anthocyanins - isolation & purification
Anthocyanins - pharmacology
anti-inflammatory agents
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Anti-Inflammatory Agents, Non-Steroidal - isolation & purification
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
antioxidants
Antioxidants - chemistry
Antioxidants - isolation & purification
Antioxidants - pharmacology
Benzopyrans - chemistry
Benzopyrans - isolation & purification
Benzopyrans - pharmacology
Biological and medical sciences
chemical constituents of plants
chemical structure
cherries
cyanidin
Cyclooxygenase Inhibitors - chemistry
Cyclooxygenase Inhibitors - isolation & purification
Cyclooxygenase Inhibitors - pharmacology
food composition
Fruit - chemistry
fruits
General pharmacology
Male
Medical sciences
medicinal plants
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Prunus cerasus
Sheep
spectral analysis
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Summary:The anthocyanins (1−3) and cyanidin isolated from tart cherries exhibited in vitro antioxidant and antiinflammatory activities comparable to commercial products. The inhibition of lipid peroxidation of anthocyanins 1−3 and their aglycon, cyanidin, were 39, 70, 75, and 57%, respectively, at 2-mM concentrations. The antioxidant activities of 1-3 and cyanidin were comparable to the antioxidant activities of tert-butylhydroquinone and butylated hydroxytoluene and superior to vitamin E at 2-mM concentrations. In the antiinflammatory assay, cyanidin gave IC50 values of 90 and 60 mM, respectively, for prostaglandin H endoperoxide synthase-1 and prostaglandin H endoperoxide synthase-2 enzymes.
ISSN:0163-3864
1520-6025
DOI:10.1021/np980501m