Crimean Congo hemorrhagic fever and diffuse alveolar haemorrhage

Although the pathology of Crimean Congo haemorrhagic fever (CCHF) is mainly related to a haemorrhagic process with secondary cytokine storm, there have been no published reports of this fatal disease being a cause of diffuse alveolar haemorrhage (DAH). There are many aetiological factors emphasizing...

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Bibliographic Details
Published in:Tropical doctor 2008-10, Vol.38 (4), p.252-254
Main Authors: Doganci, Levent, Ceyhan, Meltem, Tasdeler, Nuriye Fisgin, Sarikayalar, Hanife, Tulek, Necla
Format: Article
Language:English
Subjects:
Adult
Arboviral haemorrhagic fevers
Arboviroses
Biological and medical sciences
General aspects
Hemorrhage - etiology
Hemorrhagic Fever, Crimean - complications
Human viral diseases
Humans
Infectious diseases
Lung Diseases - etiology
Male
Medical sciences
Pulmonary Alveoli
Tropical viral diseases
Viral diseases
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Summary:Although the pathology of Crimean Congo haemorrhagic fever (CCHF) is mainly related to a haemorrhagic process with secondary cytokine storm, there have been no published reports of this fatal disease being a cause of diffuse alveolar haemorrhage (DAH). There are many aetiological factors emphasizing the direct role of endothelial injury on DAH. We present the case of a young adult Turkish man with diffuse bilateral alveolar haemorrhage without an episode of gross haemoptysis caused by the CCHF virus. Successful clinical results and a rapid clinical and radiological clearance were obtained within few days after starting daily oral ribavirin treatment. This fatal infection should be considered to exist in any patient presenting with DAH, and should rapidly be treated with ribavirin. Another very important factor which should always be borne in mind is the contagious character of the CCHF virus. It is one of the most dangerous microorganisms transmitted from person to person. Even the bronchoscopes contaminated with patient blood carry a high risk for nosocomial spread to medical staff and other patients.
ISSN:0049-4755
1758-1133
DOI:10.1258/td.2008.070406