Microvascular function relates to insulin sensitivity and blood pressure in normal subjects

A strong but presently unexplained inverse association between blood pressure and insulin sensitivity has been reported. Microvascular vasodilator capacity may be a common antecedent linking insulin sensitivity to blood pressure. To test this hypothesis, we studied 18 normotensive and glucose-tolera...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1999-02, Vol.99 (7), p.896-902
Main Authors: SERNE, E. H, STEHOUWER, C. D. A, TER MAATEN, J. C, TER WEE, P. M, RAUWERDA, J. A, DONKER, A. J. M, GANS, R. O. B
Format: Article
Language:English
Subjects:
Adult
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure - physiology
Capillaries - physiology
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Endothelium, Vascular - physiology
Female
Heart Rate - physiology
Humans
Insulin Resistance - physiology
Male
Medical sciences
Middle Aged
Reference Values
Regression Analysis
Skin - blood supply
Vasodilation - physiology
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Summary:A strong but presently unexplained inverse association between blood pressure and insulin sensitivity has been reported. Microvascular vasodilator capacity may be a common antecedent linking insulin sensitivity to blood pressure. To test this hypothesis, we studied 18 normotensive and glucose-tolerant subjects showing a wide range in insulin sensitivity as assessed with the hyperinsulinemic, euglycemic clamp technique. Blood pressure was measured by 24-hour ambulatory blood pressure monitoring. Videomicroscopy was used to measure skin capillary density and capillary recruitment after arterial occlusion. Skin blood flow responses after iontophoresis of acetylcholine and sodium nitroprusside were evaluated by laser Doppler flowmetry. Insulin sensitivity correlated with 24-hour systolic blood pressure (24-hour SBP; r=-0.50, P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.99.7.896