Early effects of total paracentesis and albumin infusion on muscle sympathetic nerve activity in cirrhotic patients with tense ascites

Background/Aims: Cirrhotic patients with ascites are characterized by a marked activation of the sympathetic and the renin-angiotensin-aldosterone system. Total paracentesis is associated with a short-lived suppression of the renin-angiotensin-aldosterone system. Little information exists as to whet...

Full description

Saved in:
Bibliographic Details
Published in:Journal of hepatology 1999, Vol.30 (1), p.95-100
Main Authors: Pozzi, Massimo, Grassi, Guido, Pecci, Valeria, Turri, Carlo, Boari, Giuseppe, Bolla, Giovanni Battista, Dell'Oro, Raffaella, Massironi, Sara, Roffi, Luigi, Mancia, Giuseppe
Format: Article
Language:English
Subjects:
Adult
Aged
Arterial baroreflexes
Ascites - etiology
Biological and medical sciences
Blood Pressure - physiology
Catecholamines
Diseases of the digestive system
Female
Heart Rate - physiology
Humans
Infusions, Intravenous
Liver Cirrhosis - complications
Liver Cirrhosis - therapy
Male
Medical sciences
Middle Aged
Muscles - innervation
Neural Inhibition - physiology
Norepinephrine - blood
Paracentesis
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Renin angiotensin aldosterone system
Serum Albumin - therapeutic use
Sympathetic nervous system
Sympathetic Nervous System - drug effects
Sympathetic Nervous System - physiopathology
Time Factors
Total paracentesis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background/Aims: Cirrhotic patients with ascites are characterized by a marked activation of the sympathetic and the renin-angiotensin-aldosterone system. Total paracentesis is associated with a short-lived suppression of the renin-angiotensin-aldosterone system. Little information exists as to whether this favourable effect is parallelled by sympathoinhibition. Methods: In 16 Child C cirrhotic patients (age: 57.1±6.2 years, mean±SEM) with tense ascites we assessed the time course of the effects of total paracentesis followed by intravenous albumin (6–8 g/l of ascites) on beat-to-beat mean arterial pressure (Finapres), heart rate, plasma norepinephrine, epinephrine (high performance liquid chromatography) and muscle sympathetic nerve activity (microneurography, peroneal nerve). Measurements were obtained under baseline conditions, during staged removal of ascitic fluid (250 ml/min) and 24 h later. The patient remained supine throughout the study period. Results: Total paracentesis (10.6±1.3 l) induced a decrease in mean arterial pressure (from 95.0±2.6 mmHg to 88.2±3.2 mmHg, p
ISSN:0168-8278
1600-0641
DOI:10.1016/S0168-8278(99)80012-9