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Analysis of a zebrafish semaphorin reveals potential functions in vivo
The semaphorin/collapsin gene family is a large and diverse family encoding both secreted and transmembrane proteins, some of which are thought to act as repulsive axon guidance molecules. However, the function of most semaphorins is still unknown. We have cloned and characterized several semaphorin...
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| Published in: | Developmental dynamics 1999-01, Vol.214 (1), p.13-25 |
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| Main Authors: | , , , , , |
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| cites | cdi_FETCH-LOGICAL-c4402-a2238205a36b20b331cf5eea7880665f3c150044309a44361ea6909d55a0c2633 |
| container_end_page | 25 |
| container_issue | 1 |
| container_start_page | 13 |
| container_title | Developmental dynamics |
| container_volume | 214 |
| creator | Halloran, Mary C. Severance, Shawn M. Yee, Charles S. Gemza, Debra L. Raper, Jonathan A. Kuwada, John Y. |
| description | The semaphorin/collapsin gene family is a large and diverse family encoding both secreted and transmembrane proteins, some of which are thought to act as repulsive axon guidance molecules. However, the function of most semaphorins is still unknown. We have cloned and characterized several semaphorins in the zebrafish in order to assess their in vivo function. Zebrafish semaZ2 is expressed in a dynamic and restricted pattern during the period of axon outgrowth that indicates potential roles in the guidance of several axon pathways. Analysis of mutant zebrafish with reduced semaZ2 expression reveals axon pathfinding errors that implicate SemaZ2 in normal guidance. Dev Dyn 1999;214:13–25. © 1999 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1097-0177(199901)214:1<13::AID-DVDY2>3.0.CO;2-3 |
| format | article |
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Dev Dyn 1999;214:13–25. © 1999 Wiley‐Liss, Inc.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>axon guidance</subject><subject>Axons - physiology</subject><subject>Branchial Region - embryology</subject><subject>Central Nervous System - embryology</subject><subject>Chickens</subject><subject>collapsin</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Mesencephalon - embryology</subject><subject>Molecular Sequence Data</subject><subject>Mutation</subject><subject>Nerve Growth Factors - genetics</subject><subject>Nerve Growth Factors - physiology</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nerve Tissue Proteins - physiology</subject><subject>Neural Crest - embryology</subject><subject>Notochord - embryology</subject><subject>Prosencephalon - embryology</subject><subject>Rhombencephalon - embryology</subject><subject>RNA, Messenger</subject><subject>semaphorin</subject><subject>Semaphorins</subject><subject>Sequence Homology, Amino Acid</subject><subject>Spinal Cord - embryology</subject><subject>zebrafish</subject><subject>Zebrafish - embryology</subject><subject>Zebrafish - genetics</subject><subject>Zebrafish - physiology</subject><subject>Zebrafish Proteins</subject><issn>1058-8388</issn><issn>1097-0177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqFkEFv00AQhVcIVErhJyD5hNqDw8yOd70baKXIoRCpUg4tlTiNNu5aXeTYwZsEpb--NolyAYnLzmje7HujT4hLhBECyI_nt7NidoFg8xQwz8_RWgt4ITEb42ek8Xgym6bT--kPeUUjGBXzTzKlF-L0-OPl0CuTGjLmtXgT408AMDrDE3FiLSqVy1NxPWlcvYshJm2VuOTJLzpXhfiYRL90q8e2C03S-a13dUxW7do36-DqpNo05Tq0TUx6eRu27VvxqupX_LtDPRPfr7_cFd_Sm_nXWTG5ScssA5k6KclIUI70QsKCCMtKee9yY0BrVVGJCiDLCKzrX43eaQv2QSkHpdREZ-LD3nfVtb82Pq55GWLp69o1vt1E1lYpIG3oeEDZtTF2vuJVF5au2zECD3yZB7480OKBFu_5cs-XkZGYe778hy8TAxdz7pve9_3hgM1i6R-OrgegvX6_13-H2u_-Cv1P5r8i9wN6BpRElFc</recordid><startdate>199901</startdate><enddate>199901</enddate><creator>Halloran, Mary C.</creator><creator>Severance, Shawn M.</creator><creator>Yee, Charles S.</creator><creator>Gemza, Debra L.</creator><creator>Raper, Jonathan A.</creator><creator>Kuwada, John Y.</creator><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199901</creationdate><title>Analysis of a zebrafish semaphorin reveals potential functions in vivo</title><author>Halloran, Mary C. ; Severance, Shawn M. ; Yee, Charles S. ; Gemza, Debra L. ; Raper, Jonathan A. ; Kuwada, John Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4402-a2238205a36b20b331cf5eea7880665f3c150044309a44361ea6909d55a0c2633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>axon guidance</topic><topic>Axons - physiology</topic><topic>Branchial Region - embryology</topic><topic>Central Nervous System - embryology</topic><topic>Chickens</topic><topic>collapsin</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Mesencephalon - embryology</topic><topic>Molecular Sequence Data</topic><topic>Mutation</topic><topic>Nerve Growth Factors - genetics</topic><topic>Nerve Growth Factors - physiology</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Nerve Tissue Proteins - physiology</topic><topic>Neural Crest - embryology</topic><topic>Notochord - embryology</topic><topic>Prosencephalon - embryology</topic><topic>Rhombencephalon - embryology</topic><topic>RNA, Messenger</topic><topic>semaphorin</topic><topic>Semaphorins</topic><topic>Sequence Homology, Amino Acid</topic><topic>Spinal Cord - embryology</topic><topic>zebrafish</topic><topic>Zebrafish - embryology</topic><topic>Zebrafish - genetics</topic><topic>Zebrafish - physiology</topic><topic>Zebrafish Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Halloran, Mary C.</creatorcontrib><creatorcontrib>Severance, Shawn M.</creatorcontrib><creatorcontrib>Yee, Charles S.</creatorcontrib><creatorcontrib>Gemza, Debra L.</creatorcontrib><creatorcontrib>Raper, Jonathan A.</creatorcontrib><creatorcontrib>Kuwada, John Y.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental dynamics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Halloran, Mary C.</au><au>Severance, Shawn M.</au><au>Yee, Charles S.</au><au>Gemza, Debra L.</au><au>Raper, Jonathan A.</au><au>Kuwada, John Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of a zebrafish semaphorin reveals potential functions in vivo</atitle><jtitle>Developmental dynamics</jtitle><addtitle>Dev Dyn</addtitle><date>1999-01</date><risdate>1999</risdate><volume>214</volume><issue>1</issue><spage>13</spage><epage>25</epage><pages>13-25</pages><issn>1058-8388</issn><eissn>1097-0177</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>The semaphorin/collapsin gene family is a large and diverse family encoding both secreted and transmembrane proteins, some of which are thought to act as repulsive axon guidance molecules. However, the function of most semaphorins is still unknown. We have cloned and characterized several semaphorins in the zebrafish in order to assess their in vivo function. Zebrafish semaZ2 is expressed in a dynamic and restricted pattern during the period of axon outgrowth that indicates potential roles in the guidance of several axon pathways. Analysis of mutant zebrafish with reduced semaZ2 expression reveals axon pathfinding errors that implicate SemaZ2 in normal guidance. Dev Dyn 1999;214:13–25. © 1999 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>9915572</pmid><doi>10.1002/(SICI)1097-0177(199901)214:1<13::AID-DVDY2>3.0.CO;2-3</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Developmental dynamics, 1999-01, Vol.214 (1), p.13-25 |
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| language | eng |
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| source | Wiley |
| subjects | Amino Acid Sequence Animals axon guidance Axons - physiology Branchial Region - embryology Central Nervous System - embryology Chickens collapsin Gene Expression Regulation, Developmental Mesencephalon - embryology Molecular Sequence Data Mutation Nerve Growth Factors - genetics Nerve Growth Factors - physiology Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Neural Crest - embryology Notochord - embryology Prosencephalon - embryology Rhombencephalon - embryology RNA, Messenger semaphorin Semaphorins Sequence Homology, Amino Acid Spinal Cord - embryology zebrafish Zebrafish - embryology Zebrafish - genetics Zebrafish - physiology Zebrafish Proteins |
| title | Analysis of a zebrafish semaphorin reveals potential functions in vivo |
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