Analysis of a zebrafish semaphorin reveals potential functions in vivo

The semaphorin/collapsin gene family is a large and diverse family encoding both secreted and transmembrane proteins, some of which are thought to act as repulsive axon guidance molecules. However, the function of most semaphorins is still unknown. We have cloned and characterized several semaphorin...

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Bibliographic Details
Published in:Developmental dynamics 1999-01, Vol.214 (1), p.13-25
Main Authors: Halloran, Mary C., Severance, Shawn M., Yee, Charles S., Gemza, Debra L., Raper, Jonathan A., Kuwada, John Y.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
axon guidance
Axons - physiology
Branchial Region - embryology
Central Nervous System - embryology
Chickens
collapsin
Gene Expression Regulation, Developmental
Mesencephalon - embryology
Molecular Sequence Data
Mutation
Nerve Growth Factors - genetics
Nerve Growth Factors - physiology
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - physiology
Neural Crest - embryology
Notochord - embryology
Prosencephalon - embryology
Rhombencephalon - embryology
RNA, Messenger
semaphorin
Semaphorins
Sequence Homology, Amino Acid
Spinal Cord - embryology
zebrafish
Zebrafish - embryology
Zebrafish - genetics
Zebrafish - physiology
Zebrafish Proteins
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Summary:The semaphorin/collapsin gene family is a large and diverse family encoding both secreted and transmembrane proteins, some of which are thought to act as repulsive axon guidance molecules. However, the function of most semaphorins is still unknown. We have cloned and characterized several semaphorins in the zebrafish in order to assess their in vivo function. Zebrafish semaZ2 is expressed in a dynamic and restricted pattern during the period of axon outgrowth that indicates potential roles in the guidance of several axon pathways. Analysis of mutant zebrafish with reduced semaZ2 expression reveals axon pathfinding errors that implicate SemaZ2 in normal guidance. Dev Dyn 1999;214:13–25. © 1999 Wiley‐Liss, Inc.
ISSN:1058-8388
1097-0177
DOI:10.1002/(SICI)1097-0177(199901)214:1<13::AID-DVDY2>3.0.CO;2-3