Mutations in a Peptidylprolyl-cis/trans-isomerase gene lead to a defect in 3'-end formation of a pre-mRNA in Saccharomyces cerevisiae

In a genetic screen aimed at the identification of trans-acting factors involved in mRNA 3'-end processing of budding yeast, we have previously isolated two temperature-sensitive mutants with an apparent defect in the 3'-end formation of a plasmid-derived pre-mRNA. Surprisingly, both mutan...

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Bibliographic Details

Published in:	The Journal of biological chemistry 1999-01, Vol.274 (1), p.108-116
Main Authors:	Hani, J. (Max-Planck-Institut fur Biochemie, Munchen, Germany.), Schelbert, B, Bernhardt, A, Domdey, H, Fisher, G, Wiebauer, K, Rahfeld, J.U
Format:	Article
Language:	eng
Subjects:	ACTIVIDAD ENZIMATICA ACTIVITE ENZYMATIQUE Amino Acid Isomerases - genetics Amino Acid Isomerases - metabolism Amino Acid Sequence ARN MENSAJERO ARN MESSAGER Base Sequence Blotting, Western CHEMICAL REACTIONS DNA Primers ENZYMIC ACTIVITY FENOTIPOS GENE GENES INDUCED MUTATION ISOMERASAS ISOMERASE ISOMERASES MESSENGER RNA Molecular Sequence Data MUTACION INDUCIDA MUTANT MUTANTES MUTANTS Mutation MUTATION PROVOQUEE NIMA-Interacting Peptidylprolyl Isomerase Peptidylprolyl Isomerase - genetics Peptidylprolyl Isomerase - metabolism PHENOTYPE PHENOTYPES PRECURSORS REACCIONES QUIMICAS REACTION CHIMIQUE Recombinant Proteins - genetics Recombinant Proteins - metabolism RNA Precursors - genetics RNA Processing, Post-Transcriptional RNA, Messenger - genetics SACCHAROMYCES CEREVISIAE Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins STRUCTURAL GENES Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic
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