On the antioxidant activity of melatonin

Melatonin has been widely reported to be an effective antioxidant. Studies of its ability to inhibit the autoxidation of lipids in homogeneous solution and in model heterogeneous systems show that melatonin is not a peroxyl radical trapping antioxidant. In contrast, melatonin can inhibit metal ion-c...

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Bibliographic Details
Published in:Free radical biology & medicine 1999, Vol.26 (1), p.117-128
Main Authors: Antunes, Fernando, Barclay, L.Ross C., Ingold, Keith U., King, Mary, Norris, James Q., Scaiano, J.C., Xi, Fengde
Format: Article
Language:English
Subjects:
Antioxidant
Antioxidants - metabolism
Antioxidants - pharmacology
Free radicals
Free Radicals - metabolism
In Vitro Techniques
Lipid Bilayers
Lipid Metabolism
Melatonin
Melatonin - metabolism
Melatonin - pharmacology
Metal chelation
Micelles
Oxidation-Reduction
Peroxides - metabolism
Solutions
Spectrometry, Fluorescence
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Summary:Melatonin has been widely reported to be an effective antioxidant. Studies of its ability to inhibit the autoxidation of lipids in homogeneous solution and in model heterogeneous systems show that melatonin is not a peroxyl radical trapping antioxidant. In contrast, melatonin can inhibit metal ion-catalyzed oxidation processes.
ISSN:0891-5849
1873-4596
DOI:10.1016/S0891-5849(98)00168-3