Analysis of CO2 vasomotor reactivity and vessel diameter changes by simultaneous venous and arterial Doppler recordings

The use of flow velocity changes in the middle cerebral artery (MCA) measured by Doppler techniques as an index of corresponding cerebral blood flow (CBF) changes is based on the assumption that the insonated arterial diameter remains stable. The postulate of unchanging vessel calibers during CBF ch...

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Bibliographic Details
Published in:Stroke (1970) 1999, Vol.30 (1), p.81-86
Main Authors: VALDUEZA, J. M, DRAGANSKI, B, HOFFMANN, O, DIRNAGL, U, EINHÄUPL, K. M
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Brain - blood supply
Carbon Dioxide - metabolism
Cerebral Arteries - physiology
Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges
Cerebral Veins - physiology
Cerebrovascular Circulation - physiology
Female
Fundamental and applied biological sciences. Psychology
Humans
Hypercapnia - diagnostic imaging
Hypercapnia - metabolism
Male
Ultrasonography, Doppler, Transcranial
Vasoconstriction - physiology
Vertebrates: nervous system and sense organs
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Summary:The use of flow velocity changes in the middle cerebral artery (MCA) measured by Doppler techniques as an index of corresponding cerebral blood flow (CBF) changes is based on the assumption that the insonated arterial diameter remains stable. The postulate of unchanging vessel calibers during CBF changes, however, is still under debate. We performed simultaneous measurements of arterial and venous blood flow velocities by transcranial Doppler ultrasound during various stages of hypercapnia to analyze diameter changes in the insonated vessels by comparing differences in the vasomotor reactivity. Simultaneous Doppler recordings of 1 MCA and of a contralateral venous vessel thought to represent the sphenoparietal sinus (SPS) were carried out with a pair of 2-MHz range-gated transducers in 16 young healthy subjects during variations of end-tidal PaCO2. During hypercapnia the mean blood flow velocity of the MCA rose from 62. 5+/-10.2 to a maximum of 99+/-12.2 cm/s (vasomotor reactivity of 60. 1+/-17.3%). The corresponding values in the SPS were significantly higher (P
ISSN:0039-2499
1524-4628
DOI:10.1161/01.STR.30.1.81