Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice

Hydrogen is an established anti-oxidant that prevents acute oxidative stress. To clarify the mechanism of hydrogen’s effect in the brain, we administered hydrogen-rich pure water (H 2) to senescence marker protein-30 (SMP30)/gluconolactonase (GNL) knockout (KO) mice, which cannot synthesize vitamin...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2008-10, Vol.375 (3), p.346-350
Main Authors: Sato, Yasunori, Kajiyama, Shizuo, Amano, Akiko, Kondo, Yoshitaka, Sasaki, Toru, Handa, Setsuko, Takahashi, Ryoya, Fukui, Michiaki, Hasegawa, Goji, Nakamura, Naoto, Fujinawa, Hikohito, Mori, Toyotaka, Ohta, Mitsuhiro, Obayashi, Hiroshi, Maruyama, Naoki, Ishigami, Akihito
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacology
Ascorbic acid
Ascorbic Acid - metabolism
Body Weight
Brain - drug effects
Brain - metabolism
Calcium-Binding Proteins - genetics
Carboxylic Ester Hydrolases - genetics
Chemiluminescence
Gluconolactonase
Hydrogen - pharmacology
Hydrogen-rich pure water
Intracellular Signaling Peptides and Proteins - genetics
Mice
Mice, Knockout
Models, Biological
Oxidative Stress
ROS
Senescence marker protein-30
Superoxide
Superoxides - antagonists & inhibitors
Superoxides - metabolism
Vitamin C
Water - pharmacology
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Summary:Hydrogen is an established anti-oxidant that prevents acute oxidative stress. To clarify the mechanism of hydrogen’s effect in the brain, we administered hydrogen-rich pure water (H 2) to senescence marker protein-30 (SMP30)/gluconolactonase (GNL) knockout (KO) mice, which cannot synthesize vitamin C (VC), also a well-known anti-oxidant. These KO mice were divided into three groups; recipients of H 2, VC, or pure water (H 2O), administered for 33 days. VC levels in H 2 and H 2O groups were
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2008.08.020