Enantiodifferential Approach for the Detection of the Target Membrane Protein of the Jasmonate Glycoside that Controls the Leaf Movement of Albizzia saman

Pairs of probes with recognition elements of opposite configuration can be used to detect target proteins of biologically active natural products. The diastereomeric probes shown were designed on the basis of structure–activity relationships determined for an endogenous factor that controls leaf ope...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2008-09, Vol.47 (38), p.7289-7292
Main Authors: Nakamura, Yoko, Miyatake, Ryoji, Ueda, Minoru
Format: Article
Language:English
Subjects:
Albizzia - drug effects
Albizzia - physiology
Amino Sugars - chemical synthesis
Amino Sugars - chemistry
Amino Sugars - metabolism
Biotin - analogs & derivatives
Biotin - chemical synthesis
Biotin - chemistry
Biotin - metabolism
chemical biology
Circadian Rhythm - drug effects
Cyclopentanes - metabolism
Cyclopentanes - pharmacology
enantiomers
Fluorescence
Fluorescent Dyes - chemistry
Glycosides - metabolism
Glycosides - pharmacology
membrane proteins
Membrane Proteins - analysis
Membrane Proteins - metabolism
natural products
Oxylipins - metabolism
Oxylipins - pharmacology
photoaffinity labeling
Photoaffinity Labels - chemical synthesis
Photoaffinity Labels - chemistry
Photoaffinity Labels - metabolism
Plant Leaves - drug effects
Plant Leaves - physiology
Plant Proteins - analysis
Plant Proteins - metabolism
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Description
Summary:Pairs of probes with recognition elements of opposite configuration can be used to detect target proteins of biologically active natural products. The diastereomeric probes shown were designed on the basis of structure–activity relationships determined for an endogenous factor that controls leaf opening and closing in the title plant. They revealed that a 38 kDa membrane protein is key to the stereospecific recognition of the natural product.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200801820