Primary mantle-cell non-Hodgkin’s lymphoma of the tongue

The evaluation of tongue swellings often represents a diagnostic challenge, because of the wide spectrum of benign and malignant possible lesions. We report a case of a patient presenting a tongue mass. An incisional biopsy was performed. Diagnosis of primary Mantle Cell non-Hodgkin’s Lymphoma of th...

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Bibliographic Details
Published in:International journal of hematology 2008-09, Vol.88 (2), p.206-208
Main Authors: Guastafierro, Salvatore, Falcone, Umberto, Celentano, Maria, Cappabianca, Salvatore, Giudice, Amerigo, Colella, Giuseppe
Format: Article
Language:English
Subjects:
Biological and medical sciences
Case Report
Female
Hematologic and hematopoietic diseases
Hematology
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma, Mantle-Cell - pathology
Magnetic Resonance Imaging
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Oncology
Tongue - pathology
Tongue Neoplasms - pathology
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Summary:The evaluation of tongue swellings often represents a diagnostic challenge, because of the wide spectrum of benign and malignant possible lesions. We report a case of a patient presenting a tongue mass. An incisional biopsy was performed. Diagnosis of primary Mantle Cell non-Hodgkin’s Lymphoma of the tongue was made by histological, immunohistochemical and cytogenetic studies. Our patient was treated with Rituximab–Cyclophosphamide, Epirubicine, Vincristine, Prednisone polychemotherapy plus Rituximab as single agent maintenance. Complete remission was achieved and no relapse has occurred during a follow-up of 53 months. We emphasize the importance of including also NHL in differential diagnosis of a tongue mass.
ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-008-0142-z