Comparative genomics of the oxidative phosphorylation system in fungi

In this study, we have carried out an in silico analysis of the available mitochondrial and nuclear genomes of fungi in order to identify the oxidative phosphorylation (OXPHOS) proteome, the complete set of proteins that perform the OXPHOS in mitochondria. The presence of OXPHOS proteins has been in...

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Bibliographic Details
Published in:Fungal genetics and biology 2008-09, Vol.45 (9), p.1248-1256
Main Authors: Lavín, José L., Oguiza, José A., Ramírez, Lucía, Pisabarro, Antonio G.
Format: Article
Language:English
Subjects:
Ascomycota
Cell Nucleus - genetics
Cell Nucleus - metabolism
Comparative genomics
Databases, Genetic
fungal proteins
Fungal Proteins - genetics
Fungal Proteins - metabolism
fungi
Fungi - classification
Fungi - genetics
Fungi - metabolism
genome
Genome, Fungal
Genomic analysis
Genomics
Microsporidia
Mitochondria
Mitochondria - genetics
Mitochondria - metabolism
mitochondrial DNA
Mitochondrial genome
molecular systematics
Nuclear genome
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
Oxidative Phosphorylation
OXPHOS
proteome
proteomics
species differences
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Summary:In this study, we have carried out an in silico analysis of the available mitochondrial and nuclear genomes of fungi in order to identify the oxidative phosphorylation (OXPHOS) proteome, the complete set of proteins that perform the OXPHOS in mitochondria. The presence of OXPHOS proteins has been investigated in 27 nuclear and 52 mitochondrial genomes of fungi. Comparative genomics reveals a high conservation of the OXPHOS system within each fungal phyla, and notable differences between the OXPHOS proteomes of the fungal phyla. The most striking differences concerned Complexes I and V. The absence of Complex I has been previously described in various species of Ascomycota and Microsporidia, and the NDUFB4 and NURM accessory subunits of Complex I appear to be specific of fungi belonging to the subphylum Pezizomycotina. In addition, the Complex V essential subunit ATP14 appears to be specific of two subphyla of Ascomycota: the Saccharomycotina and Pezizomycotina.
ISSN:1087-1845
1096-0937
DOI:10.1016/j.fgb.2008.06.005