Differential Neurophysiological Effects of Magnetic Seizure Therapy (MST) and Electroconvulsive Shock (ECS) in Non-Human Primates

Magnetic seizure therapy (MST) is under development as a means of reducing the side effects of electroconvulsive therapy (ECT) through enhanced control over patterns of seizure induction and spread. We previously reported that chronic treatment with MST resulted in less impairment in cognitive funct...

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Bibliographic Details
Published in:Clinical EEG and neuroscience 2008-07, Vol.39 (3), p.144-149
Main Authors: Cycowicz, Yael M., Luber, Bruce, Spellman, Timothy, Lisanby, Sarah H.
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Cerebral Cortex - physiopathology
Clinical outcomes
Conflicts of interest
Cross-Over Studies
Data analysis
Disease Models, Animal
Electric currents
Electric fields
Electroconvulsive therapy
Electroconvulsive Therapy - adverse effects
Electroconvulsive Therapy - methods
Electroencephalography - methods
Macaca mulatta
Magnetic fields
Male
Medical research
Monkeys & apes
Primates
Sample size
Seizures - therapy
Sensory Thresholds - physiology
Side effects
Transcranial Magnetic Stimulation - adverse effects
Transcranial Magnetic Stimulation - methods
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Summary:Magnetic seizure therapy (MST) is under development as a means of reducing the side effects of electroconvulsive therapy (ECT) through enhanced control over patterns of seizure induction and spread. We previously reported that chronic treatment with MST resulted in less impairment in cognitive function than electroconvulsive shock (ECS) in a non-human primate model of convulsive therapy. Here we present quantitative analyses of ictal expression and post-ictal suppression following ECS, MST, and anesthesia-alone sham in the same model to test whether differential neurophysiological characteristics of the seizures could be identified. Rhesus monkeys received 4 weeks of daily treatment with ECS, MST, and anesthesia-alone sham in a counterbalanced order separated by a recovery period. Both ECS and MST were given bilaterally at 2.5 × seizure threshold. Neurophysiological characteristics were derived from two scalp EEG electrode recording sites during and immediately following the ictal period, and were compared to sham treatment. EEG power within four frequencies (delta, theta, alpha and beta) was calculated. Our results support earlier findings from intracerebral electrode recordings demonstrating that MST- and ECS- induced seizures elicit differential patterns of EEG activation. Specifically, we found that ECS shows significantly more marked ictal expression, and more intense post-ictal suppression than MST in the theta, alpha, and beta frequency bands (Ps
ISSN:1550-0594
2169-5202
DOI:10.1177/155005940803900309