Reduction in Hemoglobin–Oxygen Affinity Results in the Improvement of Exercise Capacity in Mice With Chronic Heart Failure

Reduction in Hemoglobin–Oxygen Affinity Results in the Improvement of Exercise Capacity in Mice With Chronic Heart Failure Tetsuya Watanabe, Toshihiro Takeda, Shigemiki Omiya, Shungo Hikoso, Osamu Yamaguchi, Yuko Nakano, Yoshiharu Higuchi, Atsuko Nakai, Yusuke Abe, Yayoi Aki-Jin, Masayuki Taniike, I...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2008-08, Vol.52 (9), p.779-786
Main Authors: Watanabe, Tetsuya, MD, PhD, Takeda, Toshihiro, MD, PhD, Omiya, Shigemiki, MD, Hikoso, Shungo, MD, PhD, Yamaguchi, Osamu, MD, PhD, Nakano, Yuko, DDS, Higuchi, Yoshiharu, MD, PhD, Nakai, Atsuko, PhD, Abe, Yusuke, MS, Aki-Jin, Yayoi, PhD, Taniike, Masayuki, MD, PhD, Mizote, Isamu, MD, Matsumura, Yasushi, MD, PhD, Shimizu, Takahiko, PhD, Nishida, Kazuhiko, MD, PhD, Imai, Kiyohiro, PhD, Hori, Masatsugu, MD, PhD, FACC, Shirasawa, Takuji, MD, PhD, Otsu, Kinya, MD, PhD
Format: Article
Language:English
Subjects:
Aniline Compounds - therapeutic use
Animals
Antisickling Agents - therapeutic use
Biological and medical sciences
Bone marrow
Cardiology
Cardiology. Vascular system
Cardiovascular
Coronary vessels
Enzymes
Exercise
Exercise Tolerance - physiology
Fitness equipment
Globins - metabolism
Heart
Heart attacks
Heart failure
Heart Failure - drug therapy
Heart Failure - metabolism
Heart Failure - physiopathology
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Hemoglobin
Internal Medicine
Male
Medical sciences
Mice
Mice, Inbred C57BL
Muscle, Skeletal - metabolism
muscles
Musculoskeletal system
Mutation
Oxygen
Oxygen Consumption - physiology
Physical fitness
Propionates - therapeutic use
Quality of life
Rodents
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Summary:Reduction in Hemoglobin–Oxygen Affinity Results in the Improvement of Exercise Capacity in Mice With Chronic Heart Failure Tetsuya Watanabe, Toshihiro Takeda, Shigemiki Omiya, Shungo Hikoso, Osamu Yamaguchi, Yuko Nakano, Yoshiharu Higuchi, Atsuko Nakai, Yusuke Abe, Yayoi Aki-Jin, Masayuki Taniike, Isamu Mizote, Yasushi Matsumura, Takahiko Shimizu, Kazuhiko Nishida, Kiyohiro Imai, Masatsugu Hori, Takuji Shirasawa, Kinya Otsu One of the major goals of treatment for chronic heart failure is to improve exercise intolerance, a major determinant of quality of life. Here, we examined whether a reduction in hemoglobin–oxygen affinity improves exercise capacity. We transplanted bone marrow cells isolated from transgenic mice expressing a hemoglobin variant with low oxygen affinity into mice with heart failure. The transplanted mice showed improved running performance. Furthermore, administration of a synthetic allosteric modifier of hemoglobin showed a similar effect. Allosteric modification of hemoglobin represents a therapeutic option for improving exercise capacity in patients with heart failure.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2008.06.003