Plasma Cell Generation from B-Lymphocytes via CD27/CD70 Interaction

To produce antibodies, the differentiation of B cells into antibody-secreting cells, plasma cells, is required. We describe that ligation of CD27, which belongs to the tumor necrosis factor receptor (TNFR) family and is a memory marker of B cells, yields crucial signals that positively control the e...

Full description

Saved in:
Bibliographic Details
Published in:Leukemia & lymphoma 1999, Vol.35 (3-4), p.219-225
Main Authors: Agematsu, Kazunaga, Hokibara, Sho, Nagumo, Haruo, Shinozaki, Koji, Yamada, Shinji, Komiyama, Atsushi
Format: Article
Language:English
Subjects:
Animals
Antigens, CD
B-Lymphocytes - immunology
B-Lymphocytes - pathology
CD27
CD27 antigen
CD27 Ligand
CD70 antigen
Cell Differentiation - immunology
Humans
Membrane Proteins - immunology
memory B cells
plasma cell generation
plasma cells
Plasma Cells - immunology
Plasma Cells - pathology
Signal Transduction - immunology
Tumor Necrosis Factor Receptor Superfamily, Member 7 - immunology
tumor necrosis factor receptors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To produce antibodies, the differentiation of B cells into antibody-secreting cells, plasma cells, is required. We describe that ligation of CD27, which belongs to the tumor necrosis factor receptor (TNFR) family and is a memory marker of B cells, yields crucial signals that positively control the entry of B cells into the pathway to plasma cells. The triggering via CD27 by CD27 ligand (CD70) on purified peripheral blood B cells yielded an increase in the number of plasma cells in the presence of interleukin-10 (IL-10). The differentiation into plasma cells by a combination of IL-10 and CD70-transfectants occurred in CD27+ B cells, but not in CD27- B cells. Moreover, the addition of IL-2 to the IL-10 and CD70-transfectants greatly induced the differentiation into plasma cells. In the presence of only IL-2, IL-4 or IL-6, CD70-transfectants did not promote the differentiation into plasma cells. On the other hand, CD40 signaling increased the expansion of a B cell pool from peripheral blood B cells primarily activated by IL-2, IL-10 and anti-CD40 mAb. These data demonstrate that CD27 ligand (CD70) is a key molecule to direct the differentiation of CD27+ memory B cells toward plasma cells in cooperation with IL-10.
ISSN:1042-8194
1029-2403
DOI:10.3109/10428199909145724