Bone mineral density, bone remodeling and osteoprotegerin in patients with acute coronary syndrome

Abstract The objective of this study was to evaluate the relationship between coronary disease and osteoporosis and determine the effect of osteoprotegerin (OPG) on bone remodeling and bone mineral density (BMD) in a group of patients with acute coronary syndrome. Eighty-three patients (52 males and...

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Bibliographic Details
Published in:International journal of cardiology 2008-09, Vol.129 (1), p.144-145
Main Authors: Pérez-Castrillon, Jose Luis, Abad, Laura, Vega, Gemma, Sanz-Cantalapiedra, Alberto, San Miguel, Angel, Mazón, Angeles, De Luis, Daniel, Dueñas-Laita, Antonio
Format: Article
Language:English
Subjects:
Acute coronary syndrome
Acute Coronary Syndrome - diagnosis
Acute Coronary Syndrome - metabolism
Acute Coronary Syndrome - physiopathology
Aged
Biological and medical sciences
Bone Density - physiology
Bone Remodeling - physiology
Cardiology. Vascular system
Cardiovascular
Coronary heart disease
Diseases of the osteoarticular system
Female
Heart
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Myocarditis. Cardiomyopathies
Osteoarticular system. Muscles
Osteoporosis
Osteoporosis - diagnosis
Osteoporosis - metabolism
Osteoporosis - physiopathology
Osteoporosis. Osteomalacia. Paget disease
Osteoprotegerin
Osteoprotegerin - metabolism
Radiodiagnosis. Nmr imagery. Nmr spectrometry
RANKL
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Summary:Abstract The objective of this study was to evaluate the relationship between coronary disease and osteoporosis and determine the effect of osteoprotegerin (OPG) on bone remodeling and bone mineral density (BMD) in a group of patients with acute coronary syndrome. Eighty-three patients (52 males and 31 women) with acute coronary syndrome (75 patients with acute myocardial infarction and 8 with unstable angina) with an average age of 61 ± 10 years were studied. Levels of osteocalcin, urinarydeoxypyridinoline, OPG and the receptor activator of nuclear factor-κB ligand (RANKL) were determined during the hospital stay. Femoral neck, trochanter and lumbar spine densitometry was carried out using a DXA densitometer. Thirty percent of patients presented osteoporosis (39% of females and 26% of males). Osteoporotic patients were older and had a lower weight and height and elevated serum levels of osteocalcin (3.6 ± 2.25 2.63 versus ± 1.55, p = 0.05). Levels of OPG and RANKL were similar in both groups and showed no relationship with BMD. In conclusion, no relationship was observed between the OPG/RANKL system and BMD in these patients.
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2007.06.035